Publications by authors named "Pezhman Ashoo"
Article Synopsis
- The text discusses the challenges in developing effective photosensitizers for photodynamic therapy (PDT) in cancer treatment, focusing on the necessity of finding stable molecules that can operate with long-wavelength light.
- Researchers introduce a novel Ir(III)-phthalocyanine conjugate as a promising photosensitizer, utilizing its photostability and high phototoxicity with near-infrared light for more efficient PDT.
- The study shows that encapsulating this conjugate in specialized nanocapsules enhances its water solubility and effectiveness, achieving significant cancer cell growth inhibition even in low-oxygen conditions, paving the way for more reliable cancer treatment options.
A series of rhenium(I) complexes of the type -[Re(CO)(N^N)L], -, was synthesized, where N^N = benzimidazole-derived bidentate ligand with an ester functionality and L = chloride or pyridine-type ligand. The new compounds demonstrated potent activity toward ovarian A2780 cancer cells. The most active complexes, -, incorporating 4-NMepy, exhibited remarkable activity in 3D HeLa spheroids.
View Article and Find Full Text PDFRuthenium(II) complexes containing diimine ligands have contributed to the development of agents for photoactivated chemotherapy. Several approaches have been used to obtain photolabile Ru(II) complexes. The two most explored have been the use of monodentate ligands and the incorporation of steric effects between the bidentate ligands and the Ru(II).
View Article and Find Full Text PDFBackground: Due to their unique properties and potential applications in variety of areas, recently, a special attention is given to the binuclear platinum (II) complexes. They reveal a highly tunable features upon the modification of their cyclometallating and bridging ligands.
Objective: The aim of this study was to evaluate the anticancer activity and DNA binding affinity of three binuclear platinum (II) complexes, including ht-[(p-FCH)Pt(µ-PN)(µ-NP)PtMe](CFCO)(1), ht-[(p- MeCH)Pt(µ-PN)(μ-NP)Pt(p MeCH) Me] (CFCO)(2) and ht-[PtMe(µ-PN)2](CFCO) (3).