Publications by authors named "Peytremann R"
Article Synopsis
- Cytogenetic studies of 3 male patients with terminal chronic myeloid leukemia revealed chromosome abnormalities, with varying numbers of Philadelphia chromosome (Ph1) translocations: 3 Ph1 in the first, 4 in the second, and 3 in the third.
- All cases showed the typical Ph1 translocation (t(9;22)(q34;q11)) and inconsistent counts of Ph1 and 9q+ chromosomes.
- The high frequency of multiple Ph1 translocations found in this study, part of a survey on 9 blastic-phase individuals, prompts questions about their origins and clinical implications.
Article Synopsis
- Richter's syndrome is a condition where malignant lymphoma occurs alongside chronic lymphatic leukemia.
- The text presents three new cases of Richter's syndrome and compares them with existing cases from global literature.
- It also discusses the connection between these two types of lymphoid cancers.
Article Synopsis
- DDMP, a folate antagonist, was administered to 26 cancer patients at a dose of 50 mg/m² weekly, along with varying doses of CF to manage toxicity.
- Key toxic effects included myelosuppression, particularly low platelet counts and skin rashes, with 18 out of 26 patients experiencing toxicity at the lower CF dose.
- After adjusting the CF dosage, seven patients showed objective responses, including four with head and neck cancer and two with lung cancer, with most recovering from myelosuppression within 1 to 2 weeks.
[Triple Philadelphia chromosome during blastic crisis of a chronic myelocytic leukemia].
Schweiz Med Wochenschr
October 1976
The blastic phase of a Ph1-positive chronic myeloid leukemia (CML) is often characterized by hyperdiploidy and sometimes by the presence of a double Ph1, suggesting a pattern of clonal evoluation. In the case reported here, the caryotype at the time of diagnosis in 1970 was 46, XY, Ph1. In 1975, after a blastic evolution followed by a drug-induced hematologic remission, cytogenetic studies revealed a chromosomal mosaic: 47, XY, 2 Ph1 and 51, XY, 3 Ph1, 3 C, the clone with 3 Ph1 representing approximately 20% of the mitotic cells.
View Article and Find Full Text PDFA cobalamin-dependent N5-methyltetra-hydrofolate-homocysteine methyltransferase (methyl-transferase) was demonstrated in unfractioned extracts of human normal and leukemia leukocytes. Activity was substantially reduced in the absence of an added cobalamin derivative. Presumably, this residual activity reflects the endogeneous level of holoenzyme.
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