Middle Holocene Siberian genomes reveal highly connected gene pools throughout North Asia.

The peopling history of North Asia remains largely unexplored due to the limited number of ancient genomes analyzed from this region. Here, we report genome-wide data of ten individuals dated to as early as 7,500 years before present from three regions in North Asia, namely Altai-Sayan, Russian Far East, and the Kamchatka Peninsula. Our analysis reveals a previously undescribed Middle Holocene Siberian gene pool in Neolithic Altai-Sayan hunter-gatherers as a genetic mixture between paleo-Siberian and ancient North Eurasian (ANE) ancestries.

[ALLERGY PREVENTION AND TREATMENT DURING THE FIRST YEAR].

The effect of the pregnant mother's nutrition and the effect of the baby's nutrition during the first-year on the development of allergy and atopic disease in the baby have been studied extensively in recent years. Key recommendations for healthcare bodies in Europe and the United States include: • Allergy prevention in at-risk infants (parent or sibling with allergy): Currently, there is a consensus of healthcare organizations around the world that the recommended exclusive breastfeeding duration is the first 6 months of life for the overall health benefit of the baby. Allergy prevention in non-breastfed infants at risk: There are studies showing that fully hydrolyzed formula can reduce the risk of allergic reactions, especially atopic dermatitis, in high-risk non-breastfed babies.

Mastitis While Breastfeeding: Prevention, the Importance of Proper Treatment, and Potential Complications.

Mastitis is an inflammation in the breast, which may involve a bacterial infection. Breast infection during breastfeeding is a common phenomenon that requires immediate and appropriate treatment. Without proper treatment, inflammation may lead to the cessation of breastfeeding.

The Central Nervous System Effects and Mimicry of Common Variable Immunodeficiency (CVID): A Case Report with Literature Review.

There is a scarceness of information on the central nervous system effects of common variable immunodeficiency (CVID). A 30-year-old woman with a history of recurrent upper respiratory infections, vitiligo, and immune thrombocytopenic purpura presented with right-sided numbness. Magnetic resonance imaging (MRI) of the thoracic spine revealed a signal hyperintensity.

Alternative management of complex renal stones.

Introduction: The gold standard for treatment of large and complex renal stones is percutaneous nephrolithotomy (PCNL). However, in patients with significant comorbididties, this option may be suboptimal. We reviewed our experiences with ureterorenoscopy and Holmium laser lithotripsy (UL) for the primary management of large and complex intrarenal calculi.

Spinal osteomyelitis: a review of 10 years' experience.

Spinal osteomyelitis is an infrequent cause of back pain, but it can cause severe neurologic compromise or death if not treated effectively. We report 71 cases of spinal osteomyelitis. Ninety-three percent of patients complained of back pain that had been present for several weeks (average: 59 days) at the time of hospitalization.

Fulminant multiple system atrophy in a young adult presenting as motor neuron disease.

A 34-year-old man demonstrated rapidly progressive motor neuron disease and, late in his 9-month clinical course, exhibited ophthalmoplegia and dysautonomic symptoms. Neuropathology showed spinal and bulbar motor neuron disease with severe involvement of extraocular motor nuclei, degeneration of spinal sympathetic and bulbar parasympathetic nuclei, striatonigral degeneration, and early olivopontocerebellar atrophy. This case underscores the diversity of multiple system atrophy and demonstrates an unusually rapid course in a young patient.

Breast conservation therapy. Severe breast fibrosis after radiation therapy in patients with collagen vascular disease.

Two patients with collagen vascular disease (rheumatoid arthritis and scleroderma) had extremely poor cosmetic results after breast radiation therapy (RT). The patient with rheumatoid arthritis received 5251 cGy at 210 cGy per day, followed by a 1600 cGy iridium-192 implant boost. Between 8 and 11 months post-RT she had severe breast fibrosis, retraction, and pain that required a mastectomy for relief.

Failure of cyclophosphamide to prevent cerebritis in Wegener's granulomatosis.

Two patients with diffuse cerebritis due to Wegener's granulomatosis are described. The cerebritis developed despite prolonged treatment with cyclophosphamide. This may be the first report of such an occurrence.

[Diagnosis and clinical picture of oligophrenia among students with cerebral palsy].

A clinico-psychological examination covered 112 children aged 7-9 years with cerebral paralysis. The authors consider the diagnosis of intellectual disorders using traditional clinico-psychological techniques and an original technique of prediction ("Ugadaika" and Raven's matrices). the latter two methods, when combined with clinical examination, were shown to be highly informative in diagnosing oligophrenia in junior schoolchildren.

[Oligophrenia in deaf and blind children].

Combined dynamic clinical, psychological and pedagogical examination of 140 blind-and-deaf children revealed oligophrenia in 43 cases. Polymorphism and peculiar clinical manifestations in blind-and-deaf children with oligophrenia were demonstrated. A classification of oligophrenia in children with severe disorders of vision and hearing is proposed.