Publications by authors named "Petur Gunnalugur Nielsen"
Life Sci Alliance
February 2021
Article Synopsis
- Synovial sarcoma (SyS) is a type of aggressive cancer caused by a specific genetic mutation that fuses the SS18 gene with one of the SSX genes, leading to abnormal gene regulation.
- Researchers developed organoid models of SyS and conducted extensive genome profiling to uncover how this cancer alters chromatin structure and influences gene expression.
- Findings revealed that the SS18-SSX fusion disrupts normal cellular processes by changing the way chromatin is remodeled, making SyS cells reliant on specific regulators, and these changes can be reversed if the SS18-SSX fusion is removed.
