Publications by authors named "Petter Kollberg"
Article Synopsis
- * Using Swedish health data from 2006 to 2019, researchers found that 24% of BC patients and 23% of RCC patients had diabetes, and noted a correlation between cancer and poor glycemic control.
- * The study revealed that cancer patients transitioned earlier to insulin treatment compared to diabetes-only patients, and those on systemic corticosteroids were more likely to experience malglycemia, indicating a need for better management strategies.
Article Synopsis
- Limited information exists on lymph node metastases (LNMs) in upper tract urothelial carcinoma (UTUC), prompting a study to analyze their location and complications post-surgery.
- Conducted across multiple Nordic hospitals, the study involved patients with advanced UTUC, who underwent radical nephroureterectomy and lymph node dissection with specific templates for each side.
- Results indicated LNMs in about 23% of patients, with higher rates on the right side, and only a few experienced serious complications within 90 days, suggesting the templates effectively captured most LNMs without significant risks.
Background: F-Fluorodeoxyglucose positron emission combined with computed tomography (FDG-PET/CT) has been proposed to improve preoperative staging in patients with bladder cancer subjected to radical cystectomy (RC).
Objective: Our aim was to assess the accuracy of FDG-PET/CT for lymph node staging ascertained at the multidisciplinary tumour board compared to lymph node status in the surgical lymphadenectomy specimen obtained at RC, and to explore potential factors associated with false-positive FDG-PET/CT results.
Design, Setting And Participants: Consecutive patients with bladder cancer undergoing RC with extended lymph node dissection between 2011 and 2019 without preoperative chemotherapy in a tertial referral cystectomy unit were included in the study.
Article Synopsis
- - The study examines the clinical presentation and outcomes of 33 patients with suspected urosymphyseal fistula (USF) following pelvic radiotherapy, focusing on diagnostic delays, symptoms, and treatment results over a median follow-up of 22 months.
- - Out of the 24 patients diagnosed with USF, the majority were elderly males, with local pain being the most common symptom, while a significant number faced delays in diagnosis and had complications, including osteomyelitis.
- - The findings suggest that endourologic procedures in patients who have received pelvic radiotherapy should be handled with care due to associated risks and potential complications.
Background: Prophylactic lightweight mesh in the sublay position reduced the cumulative incidence of parastomal hernia (PSH) after cystectomy with ileal conduit diversion in a randomised controlled trial.
Objective: To investigate whether the use of prophylactic mesh is cost-effective in comparison to no mesh from the health care provider perspective.
Design Setting And Participants: Data on health care resource utilisation (outpatient care and inpatient care) were obtained for 159 patients included in a randomised trial.
To prospectively assess anorectal dysfunction using patient-reported outcomes using validated questionnaires, manovolumetry and endoanal ultrasound before and 12 months after RC. From 2014 to 2019, we prospectively included 44 patients scheduled for RC. Preoperatively and 12 months after surgery, 41 patients filled in a low anterior resection syndrome score (LARS-score) to assess fecal incontinence, increased frequency, urgency and emptying difficulties and a St Mark's score to assess fecal incontinence in conjunction with manovolumetry and endoanal ultrasound examinations.
View Article and Find Full Text PDFBackground: For muscle-invasive bladder cancer (MIBC), no tissue biomarkers are available for clinical use to predict response to neoadjuvant chemotherapy.
Objective: To investigate how molecular subtypes impact pathological response and survival in patients receiving preoperative cisplatin-based chemotherapy.
Design, Setting, And Participants: Classification of a retrospective cohort of 149 patients was performed by tumor transcriptomic profiling and immunostaining.
Objective: To determine whether repeated [ F]fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET-CT) scans can predict increased cancer-specific survival (CSS) after induction chemotherapy followed by radical cystectomy (RC).
Patients And Methods: Between 2007 and 2018, 86 patients with clinically lymph node (LN)-positive bladder cancer (T1-T4, N1-N3, M0-M1a) were included and underwent a repeated FDG-PET-CT during cisplatin-based induction chemotherapy. The 71 patients that had a response to chemotherapy underwent RC.
Background: Parastomal hernia (PSH) after urinary diversion with ileal conduit is frequently a clinical problem.
Objective: To investigate whether a prophylactic lightweight mesh in the sublay position can reduce the cumulative incidence of PSH after open cystectomy with ileal conduit.
Design, Setting, And Participants: From 2012 to 2017, we randomised 242 patients 1:1 to conventional stoma construction (n = 124) or prophylactic mesh (n = 118) at three Swedish hospitals (ISRCTN 95093825).
In Sweden complications after radical cystectomy have been reported to the nationwide population-based Swedish Cystectomy Registry since 2011. Here, validation of the reporting was assessed in two healthcare regions. Complications were ascertained from patient records by a third party not involved in the care delivered to 429 randomly selected patients from 949 who had undergone radical cystectomy since 2011 in four hospitals.
View Article and Find Full Text PDFObjectives: To investigate the preoperative prognostic value of molecular subtypes in relation to clinical information, histopathological findings, and molecular markers for patients with bladder cancer treated with radical cystectomy.
Patients And Methods: After standard preoperative staging, a population-based cohort of 519 patients underwent radical cystectomy between 2006 and 2011. Following pathological review of all transurethral resection of bladder tumor specimens, tissue microarrays were constructed, and RNA was extracted from formalin-fixed tissue blocks.
Objective: Patients with limited metastatic and locally advanced bladder cancer have a poor prognosis, and no definite treatment recommendations exist. However, long-term survival is possible for selected patients if surgery is combined with multiple courses of chemotherapy (i.e.
View Article and Find Full Text PDFBackground: One third of patients with stage T1 urothelial carcinoma (UC) progress to muscle-invasive disease requiring radical surgery. Thus, reliable tools are needed for risk stratification of stage T1 UC.
Objective: To investigate the extent to which stratification of stage T1 tumours into previously described molecular pathologic UC subtypes can provide improved information on tumour progression.
Objective: The aim of this study was to evaluate the clinical use of [(18)F]fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in addition to conventional preoperative radiological investigations in a defined group of patients with high-risk muscle-invasive bladder cancer.
Materials And Methods: In total, 103 patients with high-risk muscle-invasive bladder cancer defined as stage T3/T4 disease or as stage T2 with hydronephrosis or high-risk histological features, who were provisionally scheduled to undergo cystectomy, were prospectively recruited to the study. The patients were referred to FDG-PET/CT in addition to standard preoperative investigation with computed tomography (CT).