Publications by authors named "Petronilla Daniela Romeo"
Article Synopsis
- Pituitary adenomas (PAs), typically benign, can exhibit aggressive traits like rapid growth and poor treatment response, leading researchers to explore genetic and epigenetic influences on these behaviors.
- A study analyzed methylation profiles in 21 PA samples and 5 normal pituitary tissues, revealing that nonfunctioning pituitary adenomas (NFPAs) had higher methylation levels compared to growth hormone-secreting tumors (GH-omas), with significant findings in noncoding and intronic regions.
- Three hypermethylated genes linked to tumor development were identified, and the only major clinicopathological difference was a larger maximum diameter in NFPAs, highlighting the complex epigenetic landscape of pituitary tumors and the need for further research
Genetic/genomic profiling at a single-patient level is expected to provide critical information for determining inter-individual drug toxicity and potential efficacy in cancer therapy. A better definition of cancer subtypes at a molecular level, may correspondingly complement such pharmacogenetic and pharmacogenomic approaches, for more effective personalized treatments. Current pharmacogenetic/pharmacogenomic strategies are largely based on the identification of known polymorphisms, thus limiting the discovery of novel or rarer genetic variants.
View Article and Find Full Text PDFObjective: Adipocytes, regulated by insulin, represent the major peripheral source of prolactin (PRL), which play a pivotal role in energy balance, acting on adipogenesis and lipolysis. The aim of this study was to investigate whether PRL was associated with obesity-related inflammatory status and metabolic parameters. The diagnostic and prognostic role of PRL for metabolic syndrome (MS) was assessed.
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