Efficacy of amikacin, ofloxacin, pefloxacin, ciprofloxacin, enoxacin and fleroxacin in experimental left-sided Pseudomonas aeruginosa endocarditis.

The efficacies of amikacin, ofloxacin, pefloxacin, ciprofloxacin, enoxacin and fleroxacin, each as monotherapy, were evaluated in a rabbit model of induced left-sided Pseudomonas aeruginosa endocarditis. Therapy started 48 h after infection and lasted 5 days. All agents were given intramuscularly; amikacin at 7 mg/kg/12 h, and each quinolone at 35 mg/kg/12 h.

Microfilaremia from a Dirofilaria-like parasite in Greece. Case report.

In Europe, zoonotic filarial infections in humans are caused by two species, Dirofilaria immitis and Dirofilaria repens. These parasites are associated mainly with embolic infarcts of the pulmonary artery and subcutaneous nodules, respectively. An unusual dirofilarial infection in a Greek patient who showed marked eosinophilia and microfilaremia is presented.

Persistence of plasmid-carrying tetracycline-resistant Escherichia coli in a married couple, one of whom was receiving antibiotics.

This paper describes an extension to an earlier account of the coliform flora carried by a married couple, one of whom was taking tetracycline for prolonged periods. The latter phase of this study was notable for the following: first, certain tetracycline-resistant Escherichia coli O antigen types persisted in one of the participants for several weeks after tetracycline was withdrawn; second, a course of ampicillin led to replacement of the tetracycline-resistant flora by one that was ampicillin resistant, but the end of the ampicillin course led to the reappearance of the tetracycline-resistant line, even though no tetracycline was being taken; and third, the tetracycline-sensitive O75 E. coli, which appeared toward the end of the survey, had not lost their plasmid but carried a derivative in which the tetracycline resistance gene(s) had been inactivated by the insertion of an extra piece of deoxyribonucleic acid with a molecular weight of about 1 megadalton.

The persistence of R-plasmid-carrying E. coli in a married couple, one of whom was receiving antibiotics.

The aerobic Gram-negative intestinal flora of two individuals, husband and wife, has been followed for about 20 months. The wife was receiving prolonged tetracycline treatment for acne during the first year of the study and was found to carry a large proportion of tetracycline resistant E. coli in her faecal flora even after the tetracycline treatment had ended.

Spread of a single plasmid clone to an untreated individual from a person receiving prolonged tetracycline therapy.

The aerobic gram-negative intestinal flora of two individuals living in close proximity was followed for 17 months. One of these persons was receiving a prolonged tetracycline treatment for acne vulgaris and was colonized by tetracycline-resistant Escherichia coli strains throughout the survey. The other person studied received no antibiotics during the period in question, but was frequently found to excrete a number of E.

Novel R-plasmid-mediated beta-lactamase from Klebsiella aerogenes.

A novel beta-lactamase with a broad spectrum of activity against penicillins and cephalosporins has been detected in a strain of Klebsiella aerogenes. Its synthesis is mediated by an R-plasmid of molecular weight 64 x 10(6).

R-plasmid transfer in vivo in the absence of antibiotic selection pressure.

The persistence of an O18 Escherichia coli strain resistant to tetracycline, streptomycin, and sulfonamide has been followed in the fecal flora of a single individual over a period of 9 months. The strain in question carrying an R plasmid was detectable from the beginning of the survey, but it was only after a 10-day period of tetracycline therapy that it reached an all but permanent dominance in the fecal flora. No transfer of the R plasmid carried by the strain to any other coliform could be detected for 202 days after the end of tetracycline treatment.

Distribution of R plasmids among the Q-antigen types of Escherichia coli isolated from various clinical sources.

A total of 655 Escherichia coli strains from various clinical sources were O-antigen typed, and the serological properties were correlated with R-plasmid carriage. Of the 655 strains, 224 were resistant to one or more antibiotics and 148 of these carried R plasmids. The distribution of O-antigen types among the susceptible strains was similar to that reported previously by others in England.