Dextran-Graft-Polyacrylamide/Zinc Oxide Nanoparticles Inhibit of Cancer Cells in vitro and in vivo.

Introduction: Tumor drug resistance and systemic toxicity are major challenges of modern anticancer therapy. Nanotechnology makes it possible to create new materials with the required properties for anticancer therapy.

Methods: In this research, Dextran-graft-Polyacrylamide/ZnO nanoparticles were used.

Anti-cancer activity of zinc-tetraphenylporphyrin photosensitizer/dextran--polyacrylamide copolymer/Au(Ag) nanoparticle nanohybrids.

A comparative study of anti-cancer photodynamic activities of three-component zinc-tetraphenylporphyrin photosensitizer/dextran--polyacrylamide copolymer/Au(Ag) nanoparticle (ZnTPP/D--PAA/Au(Ag)NP) nanohybrids on LNCaP prostate cancer cells was carried out under 420 nm light irradiation with low power. A significant cytotoxic effect was revealed for both ZnTPP/D--PAA/AgNP and ZnTPP/D--PAA/AuNP nanohybrids, where ZnTPP/D--PAA/AgNP nanohybrids exhibited considerably higher anticancer activity (82%) compared to ZnTPP/D--PAA/AuNP nanohybrids (45%). The higher activity of silver-containing nanohybrids is rationalized based on two factors.

Combined Dextran-Graft-Polyacrylamide/Zinc Oxide Nanocarrier for Effective Anticancer Therapy in vitro.

Introduction: Cancer chemotherapy faces two major challenges - high toxicity of active substances and tumor resistance to drugs. Low toxic nanocarriers in combination with anticancer agents can significantly increase the effectiveness of therapy. Modern advances in nanotechnology make it easy to create materials with the necessary physical and chemical properties.