Publications by authors named "Petro Leka"
The cytosolic nucleic acid sensors RIG-I and cGAS induce type-I interferon (IFN)-mediated immune responses to RNA and DNA viruses, respectively. So far no connection between the two cytosolic pathways upstream of IKK-like kinase activation has been investigated. Here, we identify heterogeneous nuclear ribonucleoprotein M (hnRNPM) as a positive regulator of IRF3 phosphorylation and type-I IFN induction downstream of both cGAS and RIG-I.
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- Immune response genes vary widely among humans and mice, leading to different defense responses based on genetic differences, which can complicate research outcomes.
- This study used RNA sequencing and variant analysis to uncover significant genetic variations in a commonly used mouse model of NLRP3 deficiency, highlighting the impact of the Nlrp1 locus on macrophage activation independently of the NLRP3 status.
- The research provides a method to identify important genetic variations and evaluate contamination in transgenic mice studies, enhancing the reliability of findings in host defense research.