Publications by authors named "Petro Gjini"
Article Synopsis
- Mitochondrial dysfunction is a key factor in cardiomyopathies and heart failure, but the specific mechanisms behind these issues are not well understood, especially how they affect energy production and overall metabolism.
- Heart failure is characterized by inadequate energy (ATP) production due to oxidative phosphorylation problems, but it's crucial to look beyond just ATP levels to understand broader metabolic disruptions.
- The concept of a "mitochondrial ecosystem" illustrates how interconnected mitochondrial pathways and functions affect heart health, emphasizing the need for a comprehensive approach to study and develop treatments for heart failure.
Background: Most guidelines directing clinicians to manage valve disease are directed at single valve lesions. Limited data exists to direct our understanding of how concomitant valve disease impacts the left ventricle (LV).
Methods: We identified 2817 patients with aortic stenosis (AS) from the echocardiography laboratory database between September 2012 and June 2018 who had a LV ejection fraction (EF) ≥50%.