Impact of altered environment and early postnatal methamphetamine exposure on serotonin levels in the rat hippocampus during adolescence.

Background: Methamphetamine (MA) is a highly abused psychostimulant across all age groups including pregnant women. Because developing brain is vulnerable by the action of drugs, or other noxious stimuli, the aim of our study was to examine the effect of early postnatal administration of MA alone or in combination with enriched environment (EE) and/or stress of separate housing, on the levels of serotonin (5HT) in the hippocampus of male rat pups at three stages of adolescence (postnatal day (PND) 28, 35 and 45). MA (5 mg/kg/ml) was administered subcutaneously (sc) to pups (direct administration), or via mothers' milk between PND1 and PND12 (indirect administration).

Addressing vaccine concerns through the spectrum of vaccine acceptance.

Rationale/objective: Several studies have examined attitudes towards COVID-19 vaccines, giving prominence to hesitancy and conceptual models that seek to explain its prevalence, mostly in high-income contexts. An alternative conceptual approach that prioritises an understanding of vaccine concerns, the rationality of the questions people have, the political and media ecologies that raise them, will help recommend ways in which such concerns can be addressed. This current study employs the Spectrum of Vaccine Acceptance as a conceptual framework to explain vaccine concerns, in a low-income context.

The 'Nigerian Diet' and Its Evolution: Review of the Existing Literature and Household Survey Data.

Natural and social science studies have commonly referenced a 'typical' or 'habitual' Nigerian diet, without defining what such a diet entails. Our study, based on a systematic review of the existing literature and an analysis of household-level survey data, describes the general outline of a common Nigerian diet and how it varies based on spatial, demographic, and socio-economic characteristics. We further try to establish whether Nigeria has embarked on a dietary transition common in most modern economies, marked by a greater consumption of processed foods, fats, and sugar at the expense of traditional whole cereals and pulses.

The Effects of Local-Level Economic Inequality on Social Capital: Evidence from Andhra Pradesh, India.

How do changing levels of local economic inequality affect households' social capital? This article contributes to answering this question by examining the impact of village-level economic inequality in Andhra Pradesh on household levels of bridging and bonding social-network capital, using Two-Stage Least-Squares regressions of data from household surveys conducted between 2002 and 2014 by the Young Lives programme. The results of the study suggest that as local economic inequality rises, households' bridging social capital, measured through participation in efforts to resolve broader communal issues, declines whilst their bonding social capital, measured through membership in relatively demographically and socio-economically homogeneous voluntary associations, increases. Existing research suggests that the consequently growing fragmentation of communities along demographic and socio-economic division lines is likely to contribute to social conflicts.

The role of complementary feeding in India's high child malnutrition rates: findings from a comprehensive analysis of NFHS IV (2015-2016) data.

Unlabelled: Relative to its economic growth and poverty levels, Indian children suffer from higher levels of malnutrition than children in many other low- and middle-income countries. Research presented in this article examined the links between infant and young child feeding practices among Indian children and their rates of stunting, underweight, wasting, and anaemia, with a particular focus on the types of semisolid complementary food consumed. It did so through a comprehensive analysis of data on more than 57,000 6-to-23-month-old children obtained from the nationally representative National Family Health Survey IV (2015-2016).

Methamphetamine exposure during the first, but not the second half of prenatal development, affects social play behavior.

Methamphetamine (MA), as a psychostimulant drug that crosses the placental barrier, may disrupt the development of social play. The present study aims to examine the effect of prenatal MA (5 mg/kg) exposure during the first (gestational day (GD) 1-11) or second (GD 12-22) halves of prenatal development of rats on social play behavior. To investigate an acute effect of MA on social play in adulthood, juvenile rats were exposed to a dose of 1 mg/kg MA or saline on the test day and tested for social play for 15 min.

Electrode movement prevention - an animal model.

Electrode migration is the most common complication of spinal cord stimulation (SCS). The problem of longitudinal migration has already been solved, but lateral migration remains the most common current complication. The present article describes new electrodes fixation opportunities for the reduction of lateral migration in SCS.

Determination of new antidepressants in pharmaceuticals by thin-layer chromatography with densitometry.

A new and simple TLC-densitometry method has been developed for the simultaneous separation of the two noradrenergic and specific serotonergic antidepressants mirtazapine and mianserine and validated for their determination in commercially available tablets. The method used TLC plates precoated with silica gel 60F254 as the stationary phase, and the mobile phase consisted of hexane-isopropanol-25% ammonia (70 + 25 + 5, v/v/v). Densitometric analysis was carried out in the absorbance mode at 280 nm.