[Hemorrhagic fever with renal syndrome in Croatia--historical review].

Hemorrhagic fever with renal syndrome (HFRS) has been known from ancient times as a disease with many names, which raised great interest during the Korean war (1951-1954), occurring as a large epidemic (Korean hemorrhagic fever). Therefore, the subsequently discovered causative agent was named after the Hantaan River which runs along the 38th parallel and divides North Korea from South Korea. A similar disease was described in 1934 in Scandinavian countries (epidemic nephrosonephritis or nephropathy).

Comparison of three-day and five-day courses of azithromycin in the treatment of atypical pneumonia.

This open, randomised clinical study, conducted from June 1988 to December 1989, included 84 patients with clinical and radiological findings of atypical pneumonia. All patients were treated with a total dose of 1.5 g azithromycin, a new azalide antibiotic.

[Clinical and epidemiologic features of acute respiratory infection caused by Mycoplasma pneumoniae].

The results of clinical and laboratory analysis and treatment, as well as epidemiological features of acute respiratory infections caused by Mycoplasma pneumoniae in 390 patients have been reported. The patients were treated at the University Hospital of Infectious Diseases "Dr. Fran Mihaljević", Zagreb, between January 1, 1980, and December 31, 1985.

[Legionnaires' disease in Yugoslavia (an epicritical review of patients)].

A review of patients with Legionnaires' disease hospitalized in our Clinic from the first cases recorded in 1978 up to now has been given. The diagnosis was confirmed by indirect immunofluorescent method in 23 patients with pneumonia, using antigen and method of the Center for Disease Control Biological Products Division, Atlanta, Georgia, USA (Dr Wilkinson). Most of the patients (16) were sporadic cases and twice as less cases were from two epidemics (7).

[Mycoplasma pneumoniae: epidemiologic and clinical characteristics, pathogenesis, diagnosis and treatment].

Mycoplasma pneumoniae is a constant and very frequent causative agent of the acute respiratory infections, especially of pneumonias. Common etiologic, epidemiologic and clinical characteristics of this agent are described through a general review. New knowledge about pathogenesis and immunity is reported.

[Primary pulmonary cancer in women the the Doboj Region].

The aim of this work is primary lung cancer in female population of the Doboj district in the period 1975-88. incidence research as well as age structure, localisation, histological types, stage and diseases associated with lung cancer. A group of 114 female patients was investigated and as comparative group male patients with lung cancer in the same period was used.

[Clinical and epidemiologic characteristics of hemorrhagic fever with renal syndrome].

Clinical and epidemiological data on 16 patients with HFRS admitted to the University Hospital of Infectious Diseases in Zagreb during the past 10 years (1977-1986) are reported. In 13 of them, the diagnosis was confirmed serologically by indirect fluorescent method. All but two were men between 20 and 45 years of age (80% of patients).

[Pulmonary tuberculosis in patients with primary bronchial carcinoma].

The aim of this study was to determine the percentage of patients with lung cancer associated with pulmonary tuberculosis, and difference between those who only suffered from lung cancer and those who had lung cancer associated with any kind of pulmonary tuberculosis. In that sense two groups of patients: first one--110 lung cancer cases with different forms of pulmonary tuberculosis (investigated group), and second one--686 patients without any signs of pulmonary tuberculosis (control group) were studied and compared. Three scare cancers were squamous, three were adenocarcinoma and one undifferentiated cell type.

[Critical analysis of antibiotic therapy of acute respiratory infections caused by Mycoplasma pneumoniae].

Mycoplasma pneumoniae was the most frequently proved causative agent of pneumonia in patients hospitalized in our hospital. During the 6-year period (1980-1985), Mycoplasma pneumoniae was diagnosed in 390 patients with acute respiratory infections. Out of them 315 had pneumonia, and 75 had acute bronchitis with febrility.

The effect of culture media on the production and measurement of luminol-dependent chemiluminescence.

The effect of various media constituents on the production and measurement of luminol-dependent chemiluminescence by neutrophils stimulated by opsonized zymosan was studied. Glucose, calcium ions and magnesium ions were found to be necessary for optimal chemiluminescence although high concentrations of glucose had a detrimental effect. For our luminol-dependent system, a pH of 8.

The clinical use of human leukocyte interferon in viral infections.

This review presents the results of the clinical use of human leukocyte interferon (HLI) in certain diseases with viral etiology. Viral infections with manifestations in the eye, skin, and/or mucous membranes and in the respiratory system were treated with HLI by local application. HLI was incorporated into ointment, oil suspension, powder, dilution for inhalation, and dilution for subcutaneous and subconjunctival injections.