Prevalence and clinical picture of premenstrual syndrome in females from Bulgaria.

Background: Premenstrual syndrome (PMS) and its more severe form premenstrual dysphoric disorder (PMDD) are highly prevalent conditions, but there seems to be ethnic and cultural variances in their distribution.

Aims: To explore the prevalence of PMS/PMDD and their typical clinical features in a Bulgarian population.

Materials And Methods: This investigation was designed and executed as a cross-sectional descriptive study.

A Clinical Case of Patient Carrying Rare Pathological PSEN1 Gene Mutation (L424V) Demonstrates the Phenotypic Heterogenity of Early Onset Familial AD.

Dementia comprises several neurodegenerative disorders with similar neuropsychiatric features and Alzheimer's disease (AD) is the most common of them. Genetic factors are strongly implicated into its etiology especially for early-onset cases (EOAD) occuring before the age of 65. About 10% of these are inherited in autosomal dominant fashion pathogenic polymorphisms in three genes- APP, PSEN-1, and PSEN-2.