Publications by authors named "Petra Weiderer"
Article Synopsis
- The study explored the relationship between a specific genetic variant of the MCP-1 promoter (-2518G) and systemic sclerosis (SSc) in 18 patients versus 139 healthy controls, finding that GG homozygotes were more common in SSc patients.
- Immunohistochemical analysis showed MCP-1 expression in various skin cell types of SSc patients, while normal skin lacked this expression, suggesting its role in the disease.
- Additionally, fibroblasts from GG homozygote patients exhibited significantly higher MCP-1 expression, indicating that this genetic variant may contribute to the development of systemic sclerosis.
Patients with localized scleroderma receiving topical photodynamic therapy with 5-aminolevulinic acid show a reduction in skin tightness, suggesting that this therapy reduces skin sclerosis. To investigate potential mechanisms, the effects of 5-aminolevulinic acid and light on collagen metabolism were studied in vitro. Normal and scleroderma fibroblasts were treated with sublethal doses of 5-aminolevulinic acid and red light and transferred to three-dimensional collagen lattices.
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