Polygenic Risk: Predicting Depression Outcomes in Clinical and Epidemiological Cohorts of Youths.

Objective: Identifying risk factors for major depression and depressive symptoms in youths could have important implications for prevention efforts. This study examined the association of polygenic risk scores (PRSs) for a broad depression phenotype derived from a large-scale genome-wide association study (GWAS) in adults, and its interaction with childhood abuse, with clinically relevant depression outcomes in clinical and epidemiological youth cohorts.

Methods: The clinical cohort comprised 279 youths with major depression (mean age=14.