Self-reported adherence by MARS-CZ reflects LDL cholesterol goal achievement among statin users: validation study in the Czech Republic.

Rationale, Aims And Objectives: Measuring self-reported adherence may contribute to minimizing the risk of therapy failure. Hence, the main aim of the study was to assess the psychometric properties of the Czech version of Medication Adherence Report Scale (MARS-CZ) and its appropriateness for use in long-term statin therapy where goal levels of low-density lipoprotein cholesterol (LDL-c) should be achieved.

Methods: Anonymous structured interview was performed to determine self-reported adherence by MARS-CZ in outpatients chronically treated with statins.

Cytochrome P450 enzyme regulation by glucocorticoids and consequences in terms of drug interaction.

Introduction: Due to their multiple effects, glucocorticoids (GCs) have versatile medical uses. They can regulate many xenobiotic-metabolizing enzymes of the cytochrome P450 (CYP) superfamily, and thus, influence pharmacotherapy.

Areas Covered: The aim of this paper is to summarize the molecular effects of GCs on CYP as well as the available clinical evidence on drug-drug interactions (DDIs) between GCs and other drugs in which GCs influence the metabolism of other medicines through modifying CYP activity.

Chronically Ill Czech Patients' Beliefs About Medicines: The Psychometric Properties and Factor Structure of the BMQ-CZ.

The main objective of this study was to assess the factor structure and psychometric properties of the Czech translation of the Beliefs about Medicines Questionnaire (BMQ-CZ). It was hypothesized that the 4-factor structure of the BMQ-CZ would be confirmed and that psychometric properties would be verified by using positive or negative correlations with self-reported adherence, illness perceptions, and medication statements. A total of 627 people were approached, and 467 agreed to participate.

Information and awareness concerning ibuprofen as an ingredient in over the counter analgesics: a questionnaire-based survey of residents of retirement communities.

Convenient access to a large variety of OTC medicines presents patients with the opportunity for the self-treatment of many health problems. Yet this also brings on other health risks, especially to the elderly. A pointed lack of information about the safety of NSAIDs has been found among lay people, but no study in the Czech Republic so far has focused on the preferences of the residents' of retirement homes for particular NSAID pain relievers and these patients' level of knowledge regarding use and safety issues.