Publications by authors named "Petra Kienlin"
A subgroup of patients suffering from atopic dermatitis (AD) does not respond to biologics therapy targeting the key players of type-2 inflammation, and it is an ongoing discussion whether skin-infiltrating Th17 cells may underlie this phenomenon. This study aimed to investigate the potential of allergen-induced, immune-cell derived IL-17 on the induction of inflammatory processes in keratinocytes. Peripheral blood mononuclear cells derived from respectively sensitized AD patients were stimulated with house dust mite (HDM) extract and cell culture supernatants were applied subsequently in absence or presence of secukinumab to primary human keratinocytes.
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- Impaired virus clearance in atopic dermatitis (AD) patients can lead to severe herpes simplex infections known as eczema herpeticum (EH), with previous studies indicating a type 2 biased immune response in these patients.
- This research investigates the effect of the treatment dupilumab on the immune response to HSV-1 in AD patients, comparing those with and without a history of EH.
- Findings suggest that dupilumab lowers IgE levels in AD patients and enhances their HSV-1-specific immune response by increasing type I immune activity, while also reducing type 2 response markers.
IL-12 is a key cytokine in skewing immune responses toward Th1-like reactions. Human monocytes/macrophages produce high amounts of bioactive IL-12 when a priming signal (IFN-gamma or GM-CSF) precedes a second signal (e.g.
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