Publications by authors named "Petra Kalischewski"
Article Synopsis
- Patients with myasthenia gravis (MG) may experience more severe outcomes from COVID-19, and this study looked at how their immunosuppressive therapy (IST) affects both the risk of infection and the severity of the disease.
- Analysis of data from the German myasthenia gravis registry revealed that out of 1379 patients, 95 contracted COVID-19, with a significant portion (76%) already on IST.
- The results indicated that while IST did not increase the risk of contracting COVID-19, it was linked to a higher likelihood of hospitalization or death among those infected, highlighting the need for prevention strategies in this vulnerable population.*
Article Synopsis
- In 2017, eculizumab was approved to treat generalised myasthenia gravis (TRgMG), but the definition of treatment-refractory status is still unclear and needs clarification.* -
- A structured consensus process involving 12 experts aimed to create a simple scoring system to operationalize TRgMG status for better clinical decision making.* -
- The scoring system uses 13 specific criteria related to disease severity and treatment inefficacy, and it helps clarify eculizumab's use while establishing new criteria for future clinical studies.*
Background: Myasthenia gravis (MG) is characterized by reduced muscle endurance and often leads to respiratory complications.
Objective: A long-term respiratory muscle endurance training (RMET) based on normocapnic hyperpnea was introduced for the first time in MG patients. We investigated RMET effects on respiratory endurance (RE), MG symptoms, lung function and physical fitness and compared the results with a control group (CG).
Myasthenia gravis (MG) is characterized by reduced muscle endurance and is often accompanied by respiratory complications. Improvement of respiratory function is therefore an important objective in MG therapy. A previous study demonstrated that respiratory muscle endurance training (RMET) over four weeks increased respiratory muscle endurance of MG patients to about 200% of baseline.
View Article and Find Full Text PDFWe tested the effect of a home-based respiratory muscle endurance training in patients with mild to moderate generalized myasthenia gravis (MG) on Besinger score, lung function and respiratory muscle endurance. Ten patients performed respiratory muscle endurance training in form of normocapnic hyperpnea training at 50-60% of their maximal voluntary ventilation over 4-6 weeks. MG score, lung function and respiratory endurance were assessed before and after training period.
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