Posttraumatic stress disorder and substance use disorder in adolescent bipolar disorder.

Objective: Anxiety disorders such as posttraumatic stress disorder (PTSD) and substance use disorders (SUD) are increasingly recognized as comorbid disorders in children with bipolar disorder (BPD). This study explores the relationship between BPD, PTSD, and SUD in a cohort of BPD and non-BPD adolescents.

Methods: We studied 105 adolescents with BPD and 98 non-mood-disordered adolescent controls.