Is there a direct association between age-related eye diseases and mortality? The Rotterdam Study.

Purpose: To study mortality in subjects with age-related maculopathy (ARM), cataract, or open-angle glaucoma (OAG) in comparison with those without these disorders.

Design: Population-based prospective cohort study.

Participants: Subjects (n = 6339) aged 55 years and older from the population-based Rotterdam Study for whom complete information on eye disease status was present.

Family score as an indicator of genetic risk of primary open-angle glaucoma.

Objectives: To assess the genetic risk of open-angle glaucoma (OAG) in individuals by calculating a family score (FS), which summarizes the information of all relatives including their disease status, age, sex, and degree of kinship and to examine the genetic contribution to OAG with and without an increased intraocular pressure.

Methods: Case and control probands, derived from the Rotterdam Study, underwent the same ophthalmologic examination as their relatives. The FS of each proband was the sum of the differences between observed and expected values of OAG for all relatives.

Comparing ophthalmoscopy, slide viewing, and semiautomated systems in optic disc morphometry.

Purpose: To compare disc measurements obtained by indirect ophthalmoscopy, the Heidelberg Retina Tomograph (HRT), stereoscopic slide viewing (SSV) of color transparencies, and the Topcon ImageNet System (ImageNet).

Design: Population-based cross-sectional study.

Methods: From the Rotterdam Study, 324 subjects (567 eyes) were nonselectively included.