Results of radical surgery in women with stage IB2/IIA2 cervical cancer.

Introduction: There is ongoing discussion about the primary treatment of women with bulky early-stage cervical cancer. Because of the high number of patients who need adjuvant (chemo)radiotherapy after initial surgical treatment, some state that primary (chemo)radiotherapy should be the treatment of choice to prevent morbidity. The aim of our study is to assess the results of radical surgery for women with bulky early-stage cervical cancer in terms of recurrence patterns and survival.

Prognostic model for survival in patients with early stage cervical cancer.

Background: In the management of early stage cervical cancer, knowledge about the prognosis is critical. Although many factors have an impact on survival, their relative importance remains controversial. This study aims to develop a prognostic model for survival in early stage cervical cancer patients and to reconsider grounds for adjuvant treatment.

Can we predict vesicovaginal or rectovaginal fistula formation in patients with stage IVA cervical cancer?

Introduction: Patients with cervical carcinoma that invade the bladder or rectum (International Federation of Obstetrics and Gynecology stage IVA) have a high risk to develop vesicovaginal and/or rectovaginal fistulae. If we could identify pretreatment factors that predict fistula formation, these patients could be offered less debilitating treatment.

Materials And Methods: Data were retrieved from the database of consecutive patients diagnosed with stage IVA cervical cancer from 1992 to 2008.

Validation of existing prognostic models in patients with early-stage cervical cancer.

Objective: Models that predict survival and recurrence in patients with early-stage cervical cancer are important tools in patient management. We validated 12 existing prognostic models in an independent population of patients with early-stage cervical cancer.

Materials And Methods: We searched the literature for prognostic models in patients with surgically treated early-stage cervical cancer.

Gene expression in early stage cervical cancer.

Objective: Pelvic lymph node metastases are the main prognostic factor for survival in early stage cervical cancer, yet accurate detection methods before surgery are lacking. In this study, we examined whether gene expression profiling can predict the presence of lymph node metastasis in early stage squamous cell cervical cancer before treatment. In addition, we examined gene expression in cervical cancer compared to normal cervical tissue.

The natural course of spontaneous miscarriage: analysis of signs and symptoms in 188 expectantly managed women.

Background: Expectant management is an alternative for curettage in women with a miscarriage.

Aim: To assess the pattern of vaginal bleeding and pain in expectantly managed women with a miscarriage, and to analyse the factors predictive of a relatively quick spontaneous loss of pregnancy.

Design Of Study: Part of a study comparing expectant management with surgical evacuation.

Does diagnostic hysteroscopy in patients with stage I endometrial carcinoma cause positive peritoneal washings?

Objectives: Previous studies have shown that positive peritoneal washings may adversely affect cancer survival rates and that hysteroscopy is associated with a higher risk of positive washings in patients with endometrial carcinoma. Our aim was to assess if diagnostic hysteroscopy increases the risk of positive peritoneal washings in patients with endometrial cancer and affects the prognosis after surgery.

Study Design: Retrospective cohort study.