Publications by authors named "Petr I Kuzmin"
Article Synopsis
- Adaptive self-assembly of supramolecular protein structures is crucial for dynamic living matter, but monitoring the formation of larger protein complexes from smaller precursors is challenging.
- This study introduces a short membrane nanotube (sNT) as a tool for detecting and manipulating protein oligomerization by measuring changes in ionic conductivity due to protein interactions.
- The researchers used rigid oligoamide foldamer tapes (ROFTs) to facilitate protein binding and shuttling between membranes, demonstrating that these nanotubes can effectively track the assembly of proteins like Annexin-V into complex structures.
Topological rearrangements of biological membranes, such as fusion and fission, often require a sophisticated interplay between different proteins and cellular membranes. However, in the case of fusion proteins of enveloped viruses, even one molecule can execute membrane restructurings. Growing evidence indicates that matrix proteins of enveloped viruses can solely trigger the membrane bending required for another crucial step in virogenesis, the budding of progeny virions.
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