Publications by authors named "Petr Filipenko"
Article Synopsis
- Cancer is increasingly recognized as a channelopathy, where ion channels and transporters play a crucial role in tumor cell behavior, including survival and movement.
- Researchers are exploring venom peptides, like the terebrid snail peptide Tv1, for targeted cancer therapy, as they selectively interact with ion channels overexpressed in cancer cells.
- Tv1 effectively inhibits liver cancer cell growth and reduces tumor size in mice by binding to specific ion channels, triggering cancer cell death through calcium-dependent mechanisms and reducing cyclooxygenase-2 (COX-2) levels.
In bacteria, one primary and multiple alternative sigma (σ) factors associate with the RNA polymerase core enzyme (E) to form holoenzymes (Eσ) with different promoter recognition specificities. The alternative σ factor RpoS/σ is produced in stationary phase and under stress conditions and reprograms global gene expression to promote bacterial survival. To date, the three-dimensional structure of a full-length free σ factor remains elusive.
View Article and Find Full Text PDFArticle Synopsis
- Venom peptide toxins like conotoxins are crucial for understanding nicotinic acetylcholine receptors (nAChRs) and have potential therapeutic uses for the nervous system, yet their large size complicates computational analysis.
- The study focused on the α4β2 nAChR, relevant in nicotine addiction therapy, and developed a docking algorithm called ToxDock to analyze the conotoxin α-GID and its variants.
- ToxDock successfully identified active and inactive mutants of α-GID and demonstrated its efficacy in redocking other peptide toxins, showcasing its potential for studying various toxin-peptide interactions with ion channels.