Review of REACH Annex IV--establishing the minimum risk of a substance based on its intrinsic properties.

Registration is the main mechanism in REACH that ensures the safety of substances. However, some substances are exempted from Registration, such as those included in Annex IV. Annex IV lists substances that are exempted from Registration on the basis that 'sufficient information is known about these substances that they are considered to cause minimum risk because of their intrinsic properties'.