Impact of Cross-Sectoral Alcohol Policy on Youth Alcohol Consumption.

Objective: Cross-sectoral alcohol policy is recommended to reduce youth alcohol consumption, but little evidence is available on its effectiveness. Therefore, we examined whether regions and municipalities in the Dutch province of Noord-Brabant with stronger cross-sectoral alcohol policy showed larger reductions in alcohol consumption among adolescents aged 12-15.

Method: Strong regional cross-sectoral alcohol policy was defined as participation in a regional alcohol prevention program.

Program completion of a web-based tailored lifestyle intervention for adults: differences between a sequential and a simultaneous approach.

Background: Unhealthy lifestyle behaviors often co-occur and are related to chronic diseases. One effective method to change multiple lifestyle behaviors is web-based computer tailoring. Dropout from Internet interventions, however, is rather high, and it is challenging to retain participants in web-based tailored programs, especially programs targeting multiple behaviors.

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)).

Stages of change for moderate-intensity physical activity in deprived neighborhoods.

Background: This article describes the association of external and psychosocial factors with the stages of change for moderate-intensity physical activity among individuals with generally low socioeconomic positions.

Methods: A self-administered questionnaire among individuals aged 18-65 years (response rate 60%, n = 2781) in deprived neighborhoods in Eindhoven, The Netherlands, was conducted in September 2000. To identify factors associated with stages of change an ordinal logistic regression model, the "Threshold of Change model (TCM)", was used to analyze the data.

Impact evaluation of a Dutch community intervention to improve health-related behaviour in deprived neighbourhoods.

This study investigates the impact of a 2-year community intervention on health-related behaviour among adults aged 18-65 years living in deprived neighbourhoods in Eindhoven, The Netherlands. The intervention is evaluated in a community intervention trial with a quasi-experimental design in a longitudinal cohort survey (n=1926 and attrition rate: 31%) using postal questionnaires. In the 2-year implementation phase, more than 40 intervention activities were planned and delivered by intersectoral neighbourhood coalitions.

Stages of change for fruit and vegetable consumption in deprived neighborhoods.

This article describes the association of external and psychosocial factors on the stages of change for fruit and vegetable consumption, among 2,781 inhabitants, aged 18 to 65 years, in deprived neighborhoods (response rate 60%). To identify correlates of forward stage transition, an ordinal logistic regression model, the Threshold of Change Model (TCM), was used to analyze the data. The results indicate that men, those from Dutch origin, those with (rather) low health locus of control, those displaying risk behaviors, and those without knowledge of dietary guidelines were less likely to move from one stage to another and therefore were more likely to be in a lower stage-of-change category.