Phase II study of helical tomotherapy in the multidisciplinary treatment of oligometastatic colorectal cancer.

Background: Complete metastasectomy provides a real chance for long-term survival in patients with oligometastatic colorectal cancer (CRC). For inoperable patients, we evaluated in this study intensity-modulated and image-guided radiotherapy (IMRT-IGRT) by helical tomotherapy.

Methods: Twenty-four CRC patients with ≤ 5 metastases were enrolled, receiving a dose of 50 Gy in fractions of 5 Gy.

Pattern of failure after helical tomotherapy in head and neck cancer.

Background And Purpose: Helical tomotherapy (HT, Hi-Art TomoTherapy(®)) is a recently developed radiation device delivering highly conformal dose with a rotational gantry resulting in more uniform target doses and better avoidance of organs at risk. Treatment failure patterns in head and neck cancer (HNC) patients treated with HT were analyzed.

Patients And Methods: 63 patients with a biopsy-proven HNC were treated with HT.

The effect of tomotherapy imaging beam output instabilities on dose calculation.

A radiotherapy treatment plan is based on an anatomical 'snapshot' of the patient acquired during the preparation stage using a kVCT (kilovolt computed tomography) scanner. Anatomical changes will occur during the treatment course, in some cases requiring a new treatment plan to deliver the prescribed dose. With the introduction of 3D volumetric on-board imaging devices, it became feasible to use the produced images for dose recalculation.

Helical tomotherapy with simultaneous integrated boost for high-risk and lymph node-positive prostate cancer: early report on acute and late toxicity.

The use of whole pelvic radiotherapy (WPRT) for high-risk and lymph node-positive prostate cancer (PC) remains controversial. The purpose of this study was to evaluate the acute toxicity associated with helical tomotherapy in the treatment of high-risk and lymph node-positive prostate cancer. To do so, twenty-eight patients were treated to a dose of 54 Gy in daily fractions of 1.

Dosimetric assessment of static and helical TomoTherapy in the clinical implementation of breast cancer treatments.

Background And Purpose: Investigation of the use of TomoTherapy and TomoDirect versus conventional radiotherapy for the treatment of post-operative breast carcinoma. This study concentrates on the evaluation of the planning protocol for the TomoTherapy and TomoDirect TPS, dose verification and the implementation of in vivo dosimetry.

Materials And Methods: Eight patients with different breast cancer indications (left/right tumor, axillary nodes involvement (N+)/no nodes (N0), tumorectomy/mastectomy) were enrolled.

Preoperative helical tomotherapy and megavoltage computed tomography for rectal cancer: impact on the irradiated volume of small bowel.

Purpose: Preoperative (chemo)radiotherapy is considered to be standard of care in locally advanced rectal cancer, but is associated with significant small-bowel toxicity. The aim of this study was to explore to what extent helical tomotherapy and daily megavolt (MV) CT imaging may reduce the irradiated volume of small bowel.

Methods And Materials: A 3D-conformal radiotherapy (3D-CRT) plan with CTV-PTV margins adjusted for laser-skin marks (15, 15, and 10 mm for X, Y, and Z directions, respectively) was compared with helical tomotherapy (IMRT) using the same CTV-PTV margins, and to helical tomotherapy with margins adapted to daily MV-CT imaging (IMRT/IGRT; 8, 11, 7, and 10 mm for X, Y(ant), Y(post) and Z resp.

The use of molecular imaging to evaluate radiation fields in the adjuvant setting of breast cancer: a feasibility study.

Purpose: To evaluate standard radiation fields in locally advanced breast cancer using the information of a preoperative FDG-PET showing lymph node involvement.

Patients And Methods: In 15 consecutive patients, referred for postoperative radiotherapy, a standard simulation was performed. Planning CT was fused semiautomatically with preoperative FDG-PET, and thoracic wall/breast (clinical target volume [CTV]), lungs, and location(s) of axillary nodal involvement on FDG-PET (PET(ax)) were delineated.