Inter-laboratory validation of bioaccessibility testing for metals.

Bioelution assays are fast, simple alternatives to in vivo testing. In this study, the intra- and inter-laboratory variability in bioaccessibility data generated by bioelution tests were evaluated in synthetic fluids relevant to oral, inhalation, and dermal exposure. Using one defined protocol, five laboratories measured metal release from cobalt oxide, cobalt powder, copper concentrate, Inconel alloy, leaded brass alloy, and nickel sulfate hexahydrate.

[Estimation of reproducibility and repeatability in microbiological ring trials--robust versus conservative methods].

During the last years there was a lot of progress to be seen in the development of standardized methods for microbiological ring trials. The statistical analyzing strategies, in particular the calculation of estimations for the parameters repeatability and reproducibility, will be considered in this paper. Apart from the conservative method of the variance analysis robust methods are increasingly discussed.