Macular structure and function and the development of retinopathy in diabetes.

Background: The aim of this study was to evaluate the relationship between structural and functional changes identified with the Rarebit fovea test (RFT) in diabetic patients over two years. In addition, we evaluated whether the RFT changes at baseline can predict vascular changes detectable by conventional screening methods four to six years later.

Methods: Forty-two patients with diabetes and 42 age-matched healthy subjects underwent an initial examination.

Automated quality evaluation of digital fundus photographs.

Purpose: Retinal images acquired by means of digital photography are often used for evaluation and documentation of the ocular fundus, especially in patients with diabetes, glaucoma or age-related macular degeneration. The clinical usefulness of an image is highly dependent on its quality. We set out to develop and evaluate an automatic method of evaluating the quality of digital fundus photographs.

Measurement of optic disc parameters on digital fundus photographs: algorithm development and evaluation.

Purpose: To develop and evaluate a simple and rapid algorithm for optic disc measurements on digital fundus photographs, relying on the macula-disc centre distance as a reference when converting length expressed in pixels to metric distance.

Methods: Measurements were performed on fundus photographs from 68 normal subjects, acquired using five different cameras. The magnification factor and actual size in mum of 1 pixel was known for only one camera.

Algorithms for optimizing drug therapy.

Background: Drug therapy has become increasingly efficient, with more drugs available for treatment of an ever-growing number of conditions. Yet, drug use is reported to be sub optimal in several aspects, such as dosage, patient's adherence and outcome of therapy. The aim of the current study was to investigate the possibility to optimize drug therapy using computer programs, available on the Internet.

New perimetric techniques: a comparison between rarebit and frequency doubling technology perimetry in normal subjects and glaucoma patients.

Purpose: To compare rarebit microdot perimetry (RB) with frequency doubling technology (FDT) perimetry in normal subjects and a group of patients with ocular hypertension or glaucoma, with age-matched controls.

Materials And Methods: : Eighty-one subjects (age 17-88 years) were examined. Twenty-seven of these were patients, aged 50 to 88 years, with ocular hypertension or suspected/manifest glaucoma in at least one eye.

Concordance of high-pass resolution perimetry and frequency-doubling technology perimetry results in glaucoma: no support for selective ganglion cell damage.

Purpose: To compare the results of frequency-doubling technology perimetry (FDT), assumed to test the magnocellular visual pathway, and high-pass resolution perimetry (HRP), assumed to test the parvocellular visual pathway, in patients with ocular hypertension or glaucoma.

Patients And Methods: Forty-eight consecutive patients with glaucoma or ocular hypertension, covering the entire range of optic nerve function from normal to severely damaged, were examined on the same day using FDT and HRP.

Results: There was a linear correlation between both global and local indices in FDT and HRP (r = -0.