Antifibrogenic effects of vitamin D derivatives on mouse pancreatic stellate cells.

Aim: To study the molecular effects of three different D-vitamins, vitamin D2, vitamin D3 and calcipotriol, in pancreatic stellate cells (PSCs).

Methods: Quiescent PSCs were isolated from mouse pancreas and activated by seeding on plastic surfaces. The cells were exposed to D-vitamins as primary cultures (early-activated PSCs) and upon re-culturing (fully-activated cells).