Publications by authors named "Peter W Christopherson"
Article Synopsis
- Immune thrombocytopenia (ITP) is a prevalent acquired disorder affecting the blood clotting process primarily in dogs and less frequently in cats, leading to significant health risks in both species.
- ITP can be classified into primary (autoimmune) and secondary (triggered by other diseases), but there is a lack of systematic evaluation regarding which underlying conditions trigger secondary ITP.
- A comprehensive study developed guidelines through a structured review of literature, expert input, and consensus-building processes to create diagnostic algorithms and screening recommendations for ITP in dogs and cats.
Background: Acidemia in sick or injured horses is often due to lactic acid accumulation. Alterations in platelet function and hemostasis are among numerous deleterious effects caused by decreased physiologic pH.
Objectives: We aimed to evaluate the effect of hyperlactatemia and resultant acidemia on platelet aggregation in equine whole blood using impedance aggregometry.
Article Synopsis
- GM1 gangliosidosis is a deadly neurodegenerative disease affecting people of all ages, and new gene therapy in animal models shows promise for future human trials.
- A study developed a set of biomarkers from various body fluids and imaging techniques that reveal significant changes in GM1 patients and treated cats, indicating the therapy's effectiveness.
- Results showed improved brain function and structure in GM1 cats after gene therapy, supporting the potential for human clinical trials, with the new biomarkers being critical for measuring treatment outcomes.
An EDTA-anticoagulated blood sample collected from a 1.5-year-old, intact male, English Bulldog was submitted for a CBC. The CBC data and blood smear evaluation revealed borderline high hematocrit (54%, reference interval 37-55%), inappropriate rubricytosis, moderate leukopenia due to both mature neutropenia and lymphopenia, and mild thrombocytopenia.
View Article and Find Full Text PDFA 9-month-old male Great Dane had progressive generalized nodular dermatopathy for several months. There were > 100 raised, alopecic, firm, painful nodules throughout the skin. Aspirates from several lesions yielded moderate numbers of irregularly round or polygonal to spindle-shaped cells with mild to moderate anisocytosis and few inflammatory cells, and the cytologic interpretation was proliferation of mesenchymal or histiocytic cells.
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