Publications by Peter Vince

Publications by authors named "Peter Vince"

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Effects of a monocarboxylate transport 1 inhibitor, AZD3965, on retinal and visual function in the rat.

Annette E Allen Elizabeth A Martin Katherine Greenwood Claire Grant Peter Vince

Br J Pharmacol

October 2020

Background And Purpose: Inhibition of monocarboxylate transport 1 (MCT1) is of interest in targeting highly glycolytic tumours. However, MCT1 is expressed in retina, and so inhibition of MCT1 could affect retinal function.

Experimental Approach: AZD3965, an MCT1 inhibitor selected for clinical development, and two additional MCT1 inhibitors were evaluated for effects on visual acuity in albino (Han Wistar) rats.

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