Publications by authors named "Peter V Jenkins"
Article Synopsis
- Postpartum hemorrhage (PPH) can lead to coagulopathy, but much of the existing treatment stems from trauma data, with limited information specifically about PPH-related coagulopathy.
- A study analyzed over 11,000 childbirth cases, identifying 518 with significant PPH, uncovering rare but severe coagulopathies in a small group, characterized by massive fibrinolysis and other abnormalities.
- Findings showed that while serious hemostatic impairment is uncommon in most PPH cases, a rare subset of women faces acute obstetric coagulopathy, which significantly impacts fetal and maternal health.
Article Synopsis
- AHA is a rare bleeding disorder where the body produces antibodies against its own factor VIII, requiring treatment with recombinant porcine factor VIII (rpFVIII) to manage bleeding.
- The UKHCDO created guidelines to provide recommendations on monitoring rpFVIII treatment effectiveness in AHA patients by reviewing current literature.
- A validated one-stage clotting FVIII assay is advised for regular monitoring, and caution should be taken with chromogenic FVIII assays as they may underestimate rpFVIII levels, especially in patients treated with Emicizumab.
Tissue factor (TF) is critical for the activation of blood coagulation. TF function is regulated by the amount of externalised phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the surface of the cell in which it is expressed. We investigated the role PS and PE in fibroblast TF function.
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