Publications by authors named "Peter Toft Jensen"
Article Synopsis
- The study investigates the biological response of the supraspinatus muscle to tendon tears, highlighting significant inflammation, degeneration, and changes in tissue composition over time.
- The research involved 45 C57BL/6 mice with shoulder tendon tears, examining muscle damage at various recovery intervals using multiple analytical techniques.
- Key findings reveal peak muscle inflammation around day 5, notable changes in protein expression related to immune response and collagen accumulation, and diminished regenerative capacity of muscle cells post-injury.
TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex.
Minna Yli-Karjanmaa Kathrine Solevad Larsen Christina Dühring Fenger Lotte Kellemann Kristensen Nellie Anne Martin Peter Toft Jensen
Brain Behav Immun
November 2019
Article Synopsis
- TNF inhibitors are commonly used for chronic inflammatory diseases, but the effects of long-term TNF inhibition on the central nervous system (CNS) remain unclear.
- The study examined the impact of TNF deficiency and long-term TNF inhibition on the developing neocortex, measuring cell types and gene expression in TNF knockout and wildtype mice.
- Results showed that TNF deficiency altered brain cell composition, with nonselective TNF inhibitor etanercept impairing neurogenesis and cognitive functions, unlike the selective inhibitor XPro1595.
Article Synopsis
- The study investigates the effects of two solTNF inhibitors, XPro1595 and etanercept, on post-stroke inflammation and infarct volume in mice, comparing topical and intracerebroventricular delivery methods.
- Results indicate that only topical XPro1595 significantly reduced infarct volume at both one and three days post-stroke, while etanercept showed no impact.
- The findings suggest that topical XPro1595 alters microglial activation towards a therapeutic phenotype, highlighting its potential as a neuroprotective treatment in ischemic stroke.