Murine Multiple Sleep Latency Test: phenotyping sleep propensity in mice.

Study Objectives: Objectives were to (1) establish a measure of sleep propensity for a more comprehensive characterization of sleepiness in murine genetics and interventional studies and (2) to characterize sample sizes necessary for statistical differences in effect.

Design: Average multiple sleep latency values were compared in mice, varying strain, circadian time, and forced-wakefulness conditions.

Subjects: Adult male mice of inbred strains were studied.