Publications by authors named "Peter Tessmann"
Article Synopsis
- Nonsyndromic cleft lip and palate (nsCL/P) and nonsyndromic cleft palate only (nsCPO) are the most common types of congenital orofacial clefts, with Van der Woude syndrome being a recognized associated condition, featuring mutations in the GRHL3 gene.
- Recent sequencing studies found that nsCPO patients had a significantly higher frequency of a specific mutation (rs41268753) linked to the GRHL3 gene compared to control groups, suggesting a strong association for nsCPO.
- Additional findings revealed four novel GRHL3 mutations, insinuating that genetic counseling may indicate these mutations are more influential in cases of nonsyndromic cleft palate over the syndromic forms like
Background: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is among the most frequently occurring congenital malformations worldwide. The number of genetic loci identified as being involved in NSCL/P etiology was recently increased by a large genome-wide meta-analysis of European and Asian samples. This meta-analysis confirmed all six previously recognized genetic susceptibility loci and identified six novel ones.
View Article and Find Full Text PDFNonsyndromic cleft lip with or without cleft palate (NSCL/P), the most common type of orofacial clefting, is one of the most frequent congenital defects. Based on epidemiological data, NSCL/P can be distinguished from nonsyndromic cleft palate only (NSCPO). Both phenotypes have a complex etiology and environmental and genetic factors are involved in their development.
View Article and Find Full Text PDFFemale pattern hair loss (FPHL) is a common hair loss disorder in women with a complex mode of inheritance. Its etiopathogenesis is poorly understood. Widespread assumptions of overlapping susceptibility variants between FPHL and male pattern baldness (androgenetic alopecia) and a crucial role of androgens or distinct sexual steroid hormones in the development of FPHL could neither be clearly demonstrated nor completely excluded at the molecular level up to date.
View Article and Find Full Text PDFWe conducted a genome-wide association study (GWAS) and a follow-up study of bipolar disorder (BD), a common neuropsychiatric disorder. In the GWAS, we investigated 499,494 autosomal and 12,484 X-chromosomal SNPs in 682 patients with BD and in 1300 controls. In the first follow-up step, we tested the most significant 48 SNPs in 1729 patients with BD and in 2313 controls.
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