Maintenance of osseointegration utilizing insulin therapy in a diabetic rat model.

Background: Normal wound healing processes have been shown to be altered in diabetes, and the effect of the diabetes on bone-to-implant contact (BIC) once osseointegration has been established is still unknown. The purpose of this study was to histologically evaluate the bone-to-implant contact in uncontrolled and insulin-controlled rats in which diabetes was induced following the establishment of osseointegration.

Methods: Thirty-two rats were assigned to eight different treatment groups of four each.