Publications by authors named "Peter S Galatin"
Article Synopsis
- Cancer care guidelines emphasize the need for regular distress screening, as about one in three cancer patients experience significant distress, but implementation varies widely.
- A study at Stanford Cancer Center tested a hybrid screening method (electronic and paper) using a modified questionnaire to evaluate health and distress, incorporating workflow changes to integrate with electronic health records.
- Over 53,000 questionnaires were collected, revealing that about 40% of patients screened positively for distress, leading to significant referrals for supportive care, highlighting the method's feasibility for large-scale use.
Background: Overexpression of Bcl-2 is associated with worse prognosis for a number of cancer types. The present study was designed to determine the maximum tolerated dose (MTD) of oblimersen (antisense Bcl-2) and gemcitabine when administered to patients with refractory malignancies.
Materials And Methods: Sixteen patients with advanced solid tumors refractory to standard therapies were treated with escalating doses of oblimersen continuous, 120-h intravenous infusion given every 14 days, with a fixed-dose-rate intravenous infusion of gemcitabine administered on day 5 of each cycle.
The evaluation of a sulfonamide inhibitor of the p53-mdm2 interaction is presented. The compound was identified using 3D database searching techniques based on a computationally derived pharmacophore model of mdm2 binding. It inhibits the physical interaction of recombinant p53 and mdm2 in vitro and increases p53-dependent transcription in an mdm2-overexpressing cell line.
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