Anterior segment analysis and intraocular pressure elevation after penetrating keratoplasty and posterior lamellar endothelial keratoplasty.

Background: Peripheral anterior synechiae (PAS) is a common problem after penetrating keratoplasty (PK) and leads to intraocular pressure (IOP) elevation. This study examines the risk factors for IOP elevation and post-keratoplasty glaucoma.

Methods: A retrospective analysis was performed of 47 eyes following PK and of 65 eyes following Descemet's stripping endothelial keratoplasty (DSEK) between 2009 and 2011.

Posterior iris-claw aphakic intraocular lens implantation in children.

Purpose: To evaluate the indications, visual outcomes, and complication rate after posterior implantation of an iris-claw aphakic intraocular lens (IOL) in children.

Design: Noncomparative retrospective cohort study.

Methods: setting: Institutional practice.

Visual outcomes and complications following posterior iris-claw aphakic intraocular lens implantation combined with penetrating keratoplasty.

Background: To evaluate the indication, visual outcome, and complication rate after implantation of a posterior iris-claw aphakic intraocular lens (IOL) during penetrating keratoplasty.

Methods: This retrospective study comprised 23 eyes (23 patients) without adequate capsule support undergoing posterior iris-claw aphakic IOL implantation (Verisyse/Artisan) during penetrating keratoplasty between 2005 and 2010. Mean follow-up was 18 months (range from 12 to 37 months).

Intraocular pressure elevation and post-DSEK glaucoma after Descemet`s stripping endothelial keratoplasty.

Background: Intraocular pressure (IOP) elevation is a common problem in penetrating keratoplasty (PK), and possibly leads to graft failure. IOP elevation and secondary glaucoma may also be present after Descemet`s stripping endothelial keratoplasty (DSEK). This retrospective study analyzes the risk factors for IOP elevation and the functional outcome in those patients with post-DSEK glaucoma.

Visual outcome and complications after posterior iris-claw aphakic intraocular lens implantation.

Purpose: To evaluate the indications, visual outcomes, and complication rate after implantation of a posterior chamber iris-claw aphakic intraocular lens (IOL).

Setting: Department of Ophthalmology, University Medicine Charité Berlin, Berlin, Germany.

Design: Retrospective case series.

Relapses after surgical treatment of ocular adnexal basal cell carcinomas: 5-year follow-up at the same university centre.

Purpose: To define the efficacy of surgical resection of ocular adnexal basal cell carcinoma and to analyse possible risk factors, we determined relapse rates on a yearly basis postintervention in a cohort of patients that were treated in our hospital under comparable conditions.

Methods: A total of 366 such cases that were admitted for treatment between 2002 and 2006 were followed prospectively once yearly and tumour size and localization, histological type, functional and cosmetical outcome and relapses were recorded. In cases when the primary resection margins were not free, further resections were performed until the resection margin was histologically assessed tumour free on the basis of paraffin-fixed tissue sections.

Endothelial evaluation in the cornea bank.

The light microscope is the first-choice technique for the evaluation of organ-cultured donor corneas. For the microscopic visualization of the endothelial cells, the corneas have to be immersed in ahypotonic solution. The number of cells, their vitality and morphology are analyzed.

Influence of temporary hypothermia on corneal endothelial cell density during organ culture preservation.

Purpose: To evaluate temporary exposure to hypothermia for its effects on endothelial cell density of porcine corneas in dextran containing organ-culture medium, with regard to possible negative influences of low temperatures during the transport of corneal grafts.

Methods: Two groups of central discs from pig corneas (diameter 8 mm) were first organ-cultured (MEM with 6% dextran 500) for 24 hours at 32 degrees C. Twelve corneas were exposed to 4 degrees C in group 1 for 12 hours and to 21 degrees C in group 2 for 48 hours each.

Medial canthal reconstruction by a modified glabellar flap.

Aims: To present a modified technique for the preparation of glabellar skin flaps to reconstruct medial canthal defects.

Methods: Ten consecutively treated patients were included who had skin defects after resection of skin tumours like basal cell carcinomas in the medial canthal area of a medium vertical diameter of 2.5 cm.

Risk factors for endothelial cell loss post-keratoplasty.

Purpose: Transplant survival following penetrating keratoplasty is determined to a large extent by the course of endothelial cell density loss. Different influencing factors such as organ culture conditions, surgical trauma, exchange between donor and recipient cells, cell ageing and immune reactions can contribute to endothelial cell loss. The aim of this study was to determine the rate of endothelial cell loss in our patients and to detect dependencies on donor-and recipient-related factors.

Late spontaneous in-the-bag intraocular lens and capsular tension ring dislocation in pseudoexfoliation syndrome.

Two patients with pseudoexfoliation syndrome (PEX) in whom late spontaneous in-the-bag intraocular lens (IOL) and capsular tension ring (CTR) dislocation occurred 3 and 6 years after cataract surgery are described. The patients received CTRs because of phacodonesis due to zonular laxity. The IOLs were centered postoperatively, and there was no postoperative ocular trauma.

Endothelial cell density in porcine corneas after exposure to hypotonic solutions.

Purpose: To evaluate exposure to sucrose solution (1.8%) and hypotonic balanced salt solution (BSS) for its effects on endothelial cell density of porcine corneas.

Methods: Two groups of central discs from pig corneas were organ-cultured for 24 h.

Polyurethane stents for lacrimal duct stenoses: 5-year results.

Purpose: To present 5-year results of polyurethane stent implantation for treatment of postsaccal lacrimal duct stenoses.

Methods: Ninety-two consecutive patients admitted to our hospital for stent implantation between 1997 and 2001 were retrospectively analysed. The patients who were not re-treated in our clinic were asked by questionnaire about their satisfaction and complaints.

Outcome of rotational keratoplasty: comparison of endothelial cell loss in autografts vs allografts.

Background: The nature of chronic endothelial cell loss in homologous corneal grafts is still unclear. Possible causes are cell migration to the recipient bed and chronic subclinical immune reaction.

Objectives: To compare endothelial cell loss after autologous rotational keratoplasty and homologous keratoplasty and present the clinical outcome of patients after rotational keratoplasty.

Fibroblast growth factor-2 protects endothelial cells from damage after corneal storage at 4 degrees C.

Background: Since the introduction of cold corneoscleral segment storage prior to keratoplasty there have been continuous efforts to ameliorate the preservation media in order to better maintain the quality of the corneal epi- and endothelium. Recent studies have shown that basic fibroblast growth factor (FGF-2) preserves the viability of, for example, retinal ganglion cells and pigment epithelium cells. Therefore, we investigated the effect of different concentrations of FGF-2 added to a modified Optisol storage medium on endothelial damage after corneal storage at 4 degrees C.

Increased endothelial survival of organ-cultured corneas stored in FGF-2-supplemented serum-free medium.

Purpose: To investigate the effect of FGF-2 on corneal endothelial cell survival in porcine and human corneas during corneal storage in a serum-free medium.

Methods: Porcine and paired human corneas were stored at 32 degrees C for 9 and 22 days, respectively. One cornea of each pair was stored in a serum-free culture medium, and the mate was preserved in the same medium supplemented with 10 ng/mL FGF-2.

Outcome of penetrating keratoplasty in rheumatoid arthritis.

Background: Keratolysis in rheumatoid arthritis is a well-known disorder that may rapidly destroy the entire corneal stroma, resulting in descemetocele formation and eventually corneal perforation. The purpose of this study was to determine the anatomical and functional results of therapeutic penetrating keratoplasty (PK) in these patients.

Patients And Methods: We reviewed the charts of patients having undergone PK over a 5-year period and evaluated the outcome.