Publications by authors named "Peter Richieri"
Article Synopsis
- Aberrant expression of repeat RNAs in pancreatic ductal adenocarcinoma (PDAC) resembles viral responses, affecting tumor cells and their microenvironment.
- A study on 46 primary tumors revealed that high repeat RNA levels correlate with changes in cell identity in both PDAC cells and cancer-associated fibroblasts (CAFs).
- The distinct immune signaling pathways in PDAC and CAFs, particularly involving interferon regulatory factor 3 (IRF3), highlight how these viral-like responses impact cellular flexibility and interactions within the tumor environment.
Article Synopsis
- Scientists are trying to understand how immune cells are organized in human tumors, especially in lung cancer.
- They found special areas called 'immunity hubs' in tumors that help attract T cells and can improve responses to a type of treatment called PD-1 blockade.
- One important type of hub they discovered is called the 'stem-immunity hub,' which has a mix of special immune cells that work together in a way that can help fight the cancer better when patients get immunotherapy.
The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially-localized multicellular 'immunity hubs' defined by expression of the T cell-attracting chemokines and abundant T cells. Here, we examined immunity hubs in human pre-immunotherapy lung cancer specimens, and found that they were associated with beneficial responses to PD-1-blockade.
View Article and Find Full Text PDF