Publications by authors named "Peter Rauch"
Article Synopsis
- The immune response to COVID-19 varies between children and adults, with children showing a unique plasmablast-driven initial response after mild or asymptomatic infections.
- Four months post-infection, children exhibit an enhanced antibody response, but lower B and T cell responses compared to adults, while overall neutralizing antibody effectiveness improves in both groups.
- After one year, children show signs of immune maturation, including increased S1-specific IgA and T cell development, indicating the potential benefit of booster vaccinations to strengthen their immune memory.
Article Synopsis
- Scientists found that a protein called soluble Axl (sAxl) is released into the blood when the liver is damaged, which could help doctors check for liver diseases.*
- In a study, sAxl was compared to two other tests to see how well it could detect different levels of liver damage, and it was found to be a good indicator, especially when combined with another protein called albumin.*
- The sAxl/albumin test is cheaper and easier to do, making it useful for checking for serious liver problems when other tests are too expensive or can't be done.*
Patients with chronic liver disease (CLD) and cirrhosis are at high risk for hepatocellular carcinoma (HCC). Current diagnostic tools for HCC detection include imaging techniques and serum biomarkers such as α-fetoprotein (AFP). Yet, these methods are limited in sensitivity and specificity to accurately detect early HCC.
View Article and Find Full Text PDFAccurate Determination of Soluble Axl by Enzyme-Linked Immunosorbent Assay.
Assay Drug Dev Technol
November 2016
Levels of soluble Axl (sAxl) are routinely assessed in human sera by sandwich enzyme-linked immunosorbent assay (ELISA). Although sAxl values are suggested to diagnose different types of disorders, no uniform ELISA method is available, allowing the reliable interassay comparison between results. Furthermore, little is known about the stability of sAxl under storage conditions, which is a relevant parameter for biomedical trials.
View Article and Find Full Text PDFEarly diagnosis is the key for the successful treatment of breast cancer. A serum marker for the early detection of breast cancer could significantly reduce breast cancer morbidity and mortality by bringing the time of diagnosis at an earlier and therefore still curable stage. So far, no biomarker for the early detection is available for the clinical routine.
View Article and Find Full Text PDFNew rat monoclonal antibodies (mAbs) for DDT [1,1,1 -trichloro-2,2-bis (4-chlorophenyl) ethane], namely DDT 7C12, DDT 1C1, and DDT 1B2, were developed, characterized, and applied in ELISA both in coating antigen and in enzyme-tracer format. The latter used horseradish peroxidase (HRP) or glucose oxidase as enzymes. The lowest concentration of p,p'-DDT was determined with mAb DDT 7C12 and DDT-hapten HRP, with a test midpoint (IC50) of 0.
View Article and Find Full Text PDFUsing the lacZ operon fusion technique, the transcriptional control of the Acinetobacter calcoaceticus recA gene was studied. A low (approximately twofold) inductive capacity was observed for compounds that damage DNA and/or inhibit DNA replication, e.g.
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