A double-blind, randomised, placebo-controlled study of roxithromycin and doxycycline combination, roxithromycin alone, or matching placebo for 12 weeks in adults with frequent exacerbations of chronic obstructive pulmonary disease.

Background: Azithromycin prophylaxis has been shown to reduce COPD exacerbations but there is poor evidence for other antibiotics. We compared exacerbation rates in COPD patients with a history of frequent exacerbations (at least three moderate or severe COPD exacerbations in the past two years) during a 12-week treatment course and over a subsequent 48-week follow up period.

Results: 292 patients were randomised to one of three treatments for 12 weeks: roxithromycin 300 mg daily and doxycycline 100 mg daily (n = 101); roxithromycin 300 mg daily (n = 97); or matching placebos (n = 94).

Illness behaviour profiles in chronic pain: the Auckland experience.

Two hundred patients with chronic pain, presenting to the Auckland Hospital Pain Clinic, completed the illness behaviour questionnaire (IBQ) developed by Pilowsky and Spence in Adelaide. These authors have identified 6 taxonomic clusters from a numerical analysis of illness behaviour profiles and have described the characteristics of these groups of patients. This study reports the results of a similar analysis of IBQ scores taken from a larger group of patients and clustered using a variant of the K-means algorithm.