Determination of split renal function by PSMA imaging: comparison of Ga-PSMA-11 PET with Tc-MAG3 scintigraphy.

MAG3 scintigraphy with determination of split renal function (SRF) is a standard procedure in patients with metastasized castration-resistant prostate carcinoma (mCRPC) undergoing PSMA radioligand therapy (PSMA-RLT). These patients also receive frequent PSMA PET/CT scans for staging and follow up. PSMA is not only overexpressed in prostate cancer epithelial cells, but also physiologically overexpressed in the proximal tubular cells of the kidney.