Evaluation of Internally Cooled Radiofrequency Ablation Targeting Multiple Shoulder Nerves for Chronic Shoulder Pain Relief and Function Restoration: A Prospective Study.

Objective: Shoulder pain is a prevalent musculoskeletal disorder, affecting up to 70% of adults over their lifetime. Recently radiofrequency ablation (RFA) has gained attention as a treatment for joint pain. This study aims to evaluate the efficacy of internally cooled RFA (icRFA) in alleviating shoulder pain and improving both qualitative and quantitative measures of shoulder function.

Recurrent CT perfusion imaging abnormalities in a patient with bow hunter's syndrome.

Bow hunter's syndrome is a rare syndrome of dynamic compression of the vertebral artery leading to recurrent posterior circulation stroke and/or transient ischaemic attack. The artery is compressed by the transverse process of a cervical vertebra or other structures. We describe a man in his 20s who had recurrent posterior circulation strokes confirmed on CT perfusion imaging before a dynamic left vertebral artery stenosis was found on neck manoeuvres during digital subtraction angiography.

Pilot Study of Early Catheter Ablation and Neurological Outcomes in Atrial Fibrillation-Related Stroke: RESCUE-STROKE.

Background: Inadequate management of atrial fibrillation (AF) after stroke is associated with a worse prognosis, and the impact of early rhythm control with catheter ablation (CA) on neurological outcomes in these patients is poorly understood.

Objectives: This study sought to evaluate the impact of early rhythm control with CA in patients with new-onset AF at the time of stroke.

Methods: We performed a retrospective, observational study of patients hospitalized with stroke and new-onset AF from 2021 to 2023.

Dynamic data-driven management of atrial fibrillation with implantable cardiac monitors: The MONITOR AF study.

Background: Implantable cardiac monitors (ICMs) provide valuable insights into managing atrial fibrillation (AF). Data suggest that ICMs increase AF detection, but their impact on management is still uncertain.

Objective: We aimed to evaluate and to compare the impact of ICMs on the clinical management of AF.

Caring for young adult men with inflammatory bowel disease: Clinician and patient perspectives.

Inflammatory bowel disease (IBD) presents unique challenges for young adult men that extend beyond physical symptoms, encompassing psychosocial dimensions affecting all aspects of life. This article draws insights from a roundtable discussion facilitated by the Crohn's and Colitis Young Adults Network (CCYAN), focusing on the experiences of young men living with IBD. It sheds light on the intersections of IBD and men's sexual and reproductive health, fertility, and mental well-being while identifying gaps in care.

Wisdom of the silicon crowd: LLM ensemble prediction capabilities rival human crowd accuracy.

Human forecasting accuracy improves through the "wisdom of the crowd" effect, in which aggregated predictions tend to outperform individual ones. Past research suggests that individual large language models (LLMs) tend to underperform compared to human crowd aggregates. We simulate a wisdom of the crowd effect with LLMs.

An integrated view of the structure and function of the human 4D nucleome.

The dynamic three-dimensional (3D) organization of the human genome (the "4D Nucleome") is closely linked to genome function. Here, we integrate a wide variety of genomic data generated by the 4D Nucleome Project to provide a detailed view of human 3D genome organization in widely used embryonic stem cells (H1-hESCs) and immortalized fibroblasts (HFFc6). We provide extensive benchmarking of 3D genome mapping assays and integrate these diverse datasets to annotate spatial genomic features across scales.

PET/CT for the Opportunistic Screening of Osteoporosis and Fractures in Cancer Patients.

Purpose Of Review: In this review, we outline the different etiologies of osteoporosis in the oncologic setting and describe the basis for using PET/CT as screening tool for osteoporosis with a focus on the radiotracers [F]FDG and [F]NaF.

Recent Findings: Osteoporosis is a condition commonly affecting cancer patients due to their age, cancer-specific treatment agents, and effects of cancer. In terms of the unifying mechanism, decreased ratio of osteoblast-bone formation to osteoclast-bone resorption is responsible for causing osteoporosis.

A panel-based mutational signature of homologous recombination deficiency associates with response to PARP inhibition in metastatic castration-resistant prostate cancer.

Background: The PARP inhibitor (PARPi) olaparib is approved for homologous recombination repair (HRR) gene-altered metastatic castration-resistant prostate cancer (mCRPC). However, there is significant heterogeneity in response to PARPi in patients with mCRPC. Better clinical biomarkers are needed to identify patients likely to benefit from PARPi.

Recent Advances in Genomic Approaches for the Detection of Homologous Recombination Deficiency.

Accurate detection of homologous recombination deficiency (HRD) in cancer patients is paramount in clinical applications, as HRD confers sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors. With the advances in genome sequencing technology, mutational profiling on a genome-wide scale has become readily accessible, and our knowledge of the genomic consequences of HRD has been greatly expanded and refined. Here, we review the recent advances in HRD detection methods.

Perils and opportunities in using large language models in psychological research.

The emergence of large language models (LLMs) has sparked considerable interest in their potential application in psychological research, mainly as a model of the human psyche or as a general text-analysis tool. However, the trend of using LLMs without sufficient attention to their limitations and risks, which we rhetorically refer to as "GPTology", can be detrimental given the easy access to models such as ChatGPT. Beyond existing general guidelines, we investigate the current limitations, ethical implications, and potential of LLMs specifically for psychological research, and show their concrete impact in various empirical studies.

Complete Transection of the Abdominal Wall Secondary to Being a Rear Seat-Belted Passenger.

Garrett and Braunstein introduced the concept of the "seat belt sign" in motor vehicle collision (MVC) victims. They defined this as abdominal wall bruising from a lap belt. These signs of trauma are not uncommon.

AI deception: A survey of examples, risks, and potential solutions.

This paper argues that a range of current AI systems have learned how to deceive humans. We define deception as the systematic inducement of false beliefs in the pursuit of some outcome other than the truth. We first survey empirical examples of AI deception, discussing both special-use AI systems (including Meta's CICERO) and general-purpose AI systems (including large language models).

Contribution of retroelements to birth defects and childhood cancers.

Insertion of active retroelements-L1s, s, and SVAs-can disrupt proper genome function and lead to various disorders including cancer. However, the role of retroelements (DNRTs) in birth defects and childhood cancers has not been well characterized due to the lack of adequate data and efficient computational tools. Here, we examine whole-genome sequencing data of 3,244 trios from 12 birth defect and childhood cancer cohorts in the Gabriella Miller Kids First Pediatric Research Program.

Vesicle protrusion induced by antimicrobial peptides suggests common carpet mechanism for short antimicrobial peptides.

Short-cationic alpha-helical antimicrobial peptides (SCHAMPs) are promising candidates to combat the growing global threat of antimicrobial resistance. They are short-sequenced, selective against bacteria, and have rapid action by destroying membranes. A full understanding of their mechanism of action will provide key information to design more potent and selective SCHAMPs.

Perioperative Risk Factors for Persistent Postsurgical Pain After Inguinal Hernia Repair: Systematic Review and Meta-Analysis.

Persistent postsurgical pain (PPSP) is one of the most bothersome and disabling long-term complications after inguinal hernia repair surgery. Understanding perioperative risk factors that contribute to PPSP can help identify high-risk patients and develop risk-mitigation approaches. The objective of this study was to systematically review and meta-analyze risk factors that contribute to PPSP after inguinal hernia repair.

Using a data-driven approach to define post-COVID conditions in US electronic health record data.

Objective: To create a data-driven definition of post-COVID conditions (PCC) by directly measure changes in symptomatology before and after a first COVID episode.

Materials And Methods: Retrospective cohort study using Optum® de-identified Electronic Health Record (EHR) dataset from the United States of persons of any age April 2020-September 2021. For each person with COVID (ICD-10-CM U07.