Association of Breast Cancer Screening Behaviors With Stage at Breast Cancer Diagnosis and Potential for Additive Multi-Cancer Detection Liquid Biopsy Screening: A Claims-Based Study.

Purpose: To evaluate mammography uptake and subsequent breast cancer diagnoses, as well as the prospect of additive cancer detection a liquid biopsy multi-cancer early detection (MCED) screening test during a routine preventive care exam (PCE).

Methods: Patients with incident breast cancer were identified from five years of longitudinal Blue Health Intelligence (BHI) claims data (2014-19) and their screening mammogram and PCE utilization were characterized. Ordinal logistic regression analyses were performed to identify the association of a biennial screening mammogram with stage at diagnosis.