Publications by authors named "Peter P Kovacs"
The Na(+)/Ca(2+) exchanger (NCX) plays a major role in myocardial Ca(2+) homoeostasis, but is also considered to contribute to the electrical instability and contractile dysfunction in chronic atrial fibrillation (AF). Here we have investigated the effects of the selective NCX blocker SEA0400 in human right atrial cardiomyocytes from patients in sinus rhythm (SR) and AF in order to obtain electrophysiological evidence for putative antiarrhythmic activity of this new class of drugs. Action potentials were measured in right atrial trabeculae using conventional microelectrodes.
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- Developed a pseudorabies virus-based system to deliver the fluorescent Ca(2+) sensor troponeon to adult canine heart cells (cardiomyocytes).
- Evaluated the effectiveness of the delivery method through fluorescence comparisons and assessed the virus’s impact on cellular properties like transient outward current and calcium transients.
- Found that the troponeon was transferred with nearly 100% efficiency without altering cell health or key physiological functions after four days.