Background: The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment of malignant melanoma (MM). However, resistance to targeted and immune-checkpoint-based therapies still poses a significant problem.
Objective: Here, we mine large-scale MM proteogenomic data to identify druggable targets and forecast treatment efficacy and resistance.
The combinations of BRAF inhibitor-based targeted therapies with immune checkpoint inhibitors currently represent less common therapeutic approaches in advanced melanoma. The aim of this study was to assess the safety and efficacy of currently available melanoma treatments by conducting a systematic review and network meta-analysis. Four databases were systematically searched for randomized clinical studies that included patients with advanced/metastatic melanoma receiving chemotherapy, immune checkpoint inhibitors, BRAF/MEK inhibitor therapy, or combinations thereof.
View Article and Find Full Text PDFObjective: The mainstay therapy of hypothyroidism is levothyroxine (LT4). In most cases lifelong treatment is warranted, therefore, choosing adequate doses are of paramount significance. The purpose of this study was to assess several factors that have been proposed to influence LT4 therapy including etiology of hypothyroidism, gender, age, bodyweight, BMI, concomitant drug use, disease severity and time since diagnosis in patients with stable, adequately controlled hypothyroidism.
View Article and Find Full Text PDFAims And Objectives: To develop and evaluate the effectiveness of a structured therapeutic communication module on psychological distress and perceived needs among caregivers of critically ill patients.
Background: Caregivers of critically ill patients experience intense psychological distress, and their needs often go unexpressed or unidentified. Structured therapeutic communication enables nurses to explore and fulfill these needs.
Background: The accuracy of a diagnostic test depends on its intrinsic characteristics and the disease incidence. This study aims to depict post-test probability of Pneumocystis pneumonia (PJP), according to results of PCR and Beta-D-Glucan (BDG) tests in patients with acute respiratory failure (ARF).
Materials And Methods: Diagnostic performance of PCR and BDG was extracted from literature.
Objective: Despite improvements in glucose monitoring technologies, insulin formulations and insulin delivery systems, too many patients with type 1 diabetes (T1D) continue to struggle to meet their glycemic goals. As a result, they suffer from high rates of microvascular and macrovascular disease. Titration of insulin therapy, while essential to the care of these patients, is often limited by undesirable side effects of hypoglycemia and weight gain.
View Article and Find Full Text PDFUnlabelled: The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment of malignant melanoma (MM). However, resistance to targeted and immune-checkpoint-based therapies still poses a significant problem. Here we mine large scale MM proteogenomic data integrating it with MM cell line dependency screen, and drug sensitivity data to identify druggable targets and forecast treatment efficacy and resistance.
View Article and Find Full Text PDFIntroduction: Although a positive correlation has been shown to exist between blood pressure (BP) and anthropometry, conflicting reports have been documented about the anthropometric parameter that best determines increased blood pressure (BP) in children. Whereas waist circumference (WC) has been shown to correlate with BP in adults due to disproportionate fat distribution, the uniform fat distribution in children may alter this relationship established in the adult population.
Objective: Correlation between anthropometric parameters and BP in children.
Sci Total Environ
January 2024
Dissolved Organic Matter (DOM) plays a pivotal role in influencing metal binding and mobility within lagoon sediments. However, there exists a gap in understanding the compositional alterations of DOM concerning Rare Earth Elements (REEs) across varying pollution gradients. This study aimed to characterize DOM and examine its relationship with REEs in sediment cores from different pollution levels in Yundang Lagoon, China using excitation-emission matrix-parallel factor analysis (EEM-PARAFAC).
View Article and Find Full Text PDFBackground: Arrhythmia is a known complication of rheumatic heart disease (RHD). It is critical to recognize arrhythmias early on so that prompt preventative actions and vigilant monitoring may be considered while treating these patients.
Aim: This study aimed at determining the prevalence, clinical characteristics and echocardiographic parameters of arrhythmias among RHD patients attending Jakaya Kikwete Cardiac Institute (JKCI).
The complex was prepared with preyssler polyoxoanion and transition metal (Mo), a cationic surfactant as a connector. It has tuneable physical and chemical potential which has been exploited to study novel properties. A new technique of shock wave impulses is also used on the Mo-PHP complex.
View Article and Find Full Text PDFA novel keggin-type tetra-metalates substituted polyoxometalate was functionalized by 3-(aminopropyl)-imidazole (3-API) supporting a ligand substitution method. In this paper, polyoxometalate (POMs) (NH) [PMoO] and transition metal substituted of (NH) [{PMMoO}.(HO)] (M = Mn, V) are used as one of the adsorbents.
View Article and Find Full Text PDFWe investigate numerous structural connections between numerical algorithms for partial differential equations (PDEs) and neural architectures. Our goal is to transfer the rich set of mathematical foundations from the world of PDEs to neural networks. Besides structural insights, we provide concrete examples and experimental evaluations of the resulting architectures.
View Article and Find Full Text PDFDissolved organic matter (DOM), known as a key to the aquatic carbon cycle, is influenced by abiotic and biotic factors. However, the compositional variation and these factors' effects on fluorescence DOM (FDOM) in urban rivers undergoing different anthropogenic pressure are poorly investigated. Herein, using fluorescence excitation-emission matrix and parallel factor analysis (EEM-PARAFAC), four FDOM components (C1, C2, C3, and C4) were identified in a less urbanized north river (NR) and a more urbanized west river (WR) of Jiulong River Watershed in Fujian province, China.
View Article and Find Full Text PDFBackground: Type 2 diabetes mellitus (T2DM) is a significant health burden globally, with uncontrolled DM often resulting in short- and long-term complications. Unfortunately, healthcare providers have little control over patients' necessary lifestyle modification practices outside the consultation room.
Aim: To determine the level of knowledge, attitude and practice (KAP) of lifestyle modifications among patients with T2DM attending the National District Hospital Outpatient Department, Bloemfontein, and identify possible barriers to lifestyle modifications experienced by patients.
Partial differential equation models and their associated variational energy formulations are often rotationally invariant by design. This ensures that a rotation of the input results in a corresponding rotation of the output, which is desirable in applications such as image analysis. Convolutional neural networks (CNNs) do not share this property, and existing remedies are often complex.
View Article and Find Full Text PDFThe 'twinkle' or 'twinkling' artifact represents a phenomenon observed using color Doppler ultrasound that leads to a rapid alternation of color in and immediately behind an echogenic and highly reflective object. It occurs during sonographic examination of kidney stones, and has been also described in clips used for marking breast and axillary lesions.
View Article and Find Full Text PDFNowadays, a novel contact-force guided ablation technique is used for enclosing pulmonary veins in patients with atrial fibrillation (AF). We sought to determine whether left atrial (LA) wall thickness (LAWT) and pulmonary vein (PV) dimensions, as assessed by cardiac CT, could influence the success rate of first-pass pulmonary vein isolation (PVI). In a single-center, prospective study, we enrolled consecutive patients with symptomatic, drug-refractory AF who underwent initial radiofrequency catheter ablation using a modified CLOSE protocol.
View Article and Find Full Text PDFEur J Nucl Med Mol Imaging
June 2022
Purpose: Accurate glioma classification affects patient management and is challenging on non- or low-enhancing gliomas. This study investigated the clinical value of different chemical exchange saturation transfer (CEST) metrics for glioma classification and assessed the diagnostic effect of the presence of abundant fluid in glioma subpopulations.
Methods: Forty-five treatment-naïve glioma patients with known isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion status received CEST MRI (B = 2μT, T = 3.
The mutual interaction of a microalga Chlorella vulgaris with four antibiotics viz. sulfamethoxazole (SMX), trimethoprim (TMP), azithromycin (AZI), and levofloxacin (LEV) individually and in mixture was studied in batch culture. SMX, TMP, and LEV stimulated algal growth, while AZI inhibited its growth.
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