Publications by authors named "Peter Ojakovo"
Titanium dioxide (in the form of E171) is a ubiquitous excipient in tablets and capsules for oral use. In the coating of a tablet or in the shell of a capsule the material disperses visible and UV light so that the contents are protected from the effects of light, and the patient or caregiver cannot see the contents within. It facilitates elegant methods of identification for oral solid dosage forms, thus aiding in the battle against counterfeit products.
View Article and Find Full Text PDFTwin screw wet granulation (TSWG) has gained momentum in the pharmaceutical industry for effective continuous granulation of solid dosage products. Liquid-to-solid (L/S) ratio is a key process parameter affecting granule properties. Identifying an optimum range of L/S ratio while reducing the number of full scale experiments can minimize material requirements and streamline formulation and process development.
View Article and Find Full Text PDFArticle Synopsis
- Raman chemical mapping was utilized to analyze the distribution of magnesium stearate on tablet surfaces, employing a punch-face lubrication system with varying spraying rates for placebo and active tablets.
- Principal component analysis helped break down the complex data from the Raman mapping, revealing insights into magnesium stearate presence through overlapping spectral loadings.
- In placebo tablets, magnesium stearate was detectable, while in active formulations, its identification was hindered by the dominant spectral signals from the active pharmaceutical ingredient.