Deep learning identifies morphological patterns of homologous recombination deficiency in luminal breast cancers from whole slide images.

Homologous recombination DNA-repair deficiency (HRD) is becoming a well-recognized marker of platinum salt and polyADP-ribose polymerase inhibitor chemotherapies in ovarian and breast cancers. While large-scale screening for HRD using genomic markers is logistically and economically challenging, stained tissue slides are routinely acquired in clinical practice. With the objectives of providing a robust deep-learning method for HRD prediction from tissue slides and identifying related morphological phenotypes, we first show that digital pathology workflows are sensitive to potential biases in the training set, then we propose a method to overcome the influence of these biases, and we develop an interpretation method capable of identifying complex phenotypes.

Segmentation of Nuclei in Histopathology Images by Deep Regression of the Distance Map.

The advent of digital pathology provides us with the challenging opportunity to automatically analyze whole slides of diseased tissue in order to derive quantitative profiles that can be used for diagnosis and prognosis tasks. In particular, for the development of interpretable models, the detection and segmentation of cell nuclei is of the utmost importance. In this paper, we describe a new method to automatically segment nuclei from Haematoxylin and Eosin (H&E) stained histopathology data with fully convolutional networks.

Long-term exposure to sensory feed additives during the gestational and postnatal periods affects sows' colostrum and milk sensory profiles, piglets' growth, and feed intake.

This study investigated the effect of feed supplementation in sows and/or their progeny with 2 sensory feed additives (FA1: limonene and cinnamaldehyde; FA2: menthol, carvone, and anethole) on sows' feed intake, body weight, fat deposition, and colostrum/milk composition, as well as piglets' feed intake growth and feed efficiency from birth to slaughter at postnatal day 160 (PND160). During the last third of gestation and the whole of lactation, sows were subjected to a control diet (C) or the same diet containing FA1 or FA2 at 0.1% of complete feed content.

Orthopaedic initiative for the Gaza Strip, Palestine.

The current challenges facing the health care system are best described as "acute on top of chronic", where the Palestinian health system has suffered for long years from scarcity of resources, plurality, lack of coordination and integration, unclear roles of the MOH and lack of strategic direction and leadership. The described above feature has demonstrated itself in the widely perceived fragmentation, inequity of services availability and provision, duplication of services, increasing vulnerability of population and fragility of health institutions, and threatened chances of sustainability of the Palestinian health systems with its four major players particularly the NGO sector. This combination of economic and social deterioration and the inability of health services to respond to the consequences of the situation have exacerbated the already dire health status of the population of Gaza and necessitate rapid interventions (EUNIDA, Final report: Damage assessment and needs identification in the Gaza Strip, March 2009, ECESG, January 2010).