Influence of computer-aided detection false-positives on reader performance and diagnostic confidence for CT colonography.

Objective: The objective of our study was to investigate whether an increasing number of computer-aided detection (CAD) false-positives decreases reader sensitivity, specificity, and confidence for nonexpert readers of CT colonography (CTC).

Materials And Methods: Fifty CTC data sets (29 men; mean age, 65 years), 25 of which contained 35 polyps > or = 5 mm, were selected in which CAD had 100% polyp sensitivity at two sphericity settings (0 and 75) but differed in the number of false-positives. The data sets were read by five readers twice: once at each sphericity setting.