Publications by authors named "Peter Mihalcin"
J Biol Chem
February 2020
Article Synopsis
- - The protein GcHK, found in soil bacteria, functions as a heme-based oxygen sensor and has an autophosphorylation ability that's activated by oxygen binding in its globin domain.
- - The study reveals the importance of a specific amino acid, Tyr-15, in facilitating the dimerization of the globin domain, which is crucial for the protein's function as it affects signal transduction and enzymatic activity.
- - Structural and biophysical analyses demonstrate that variants of GcHK with altered Tyr-15 lose enzymatic function, highlighting the significant role of this residue in the protein's overall signaling mechanism.
